Surgery – Instruments – Sutureless closure
Patent
1988-08-23
1991-01-01
Cannon, Alan W.
Surgery
Instruments
Sutureless closure
623 66, A61B 1704
Patent
active
049814834
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
The present invention relates to medicine and has particular reference to a biocompatible material for treatment of tissular or organic defects.
PRIOR ART
Known in the present state of the art is a composition for connective elements of soft tissues and organs based on resorbable-polymers and comprising a copolymer of N-vinyl-pyrrolidone and alkyl acrylates and/or alkyl methacrylates which contain 2 to 8 carbon atoms in their alkyl group (BE,A, N 899078). The connective elements are in fact sheets and films of preset configuration and are employed mostly in reuniting and hermetically sealing incised or resected portions of the parenchymatous organs. The film is resorbed in the organism within 35 to 250 days, its tensile strength ranging within 6.7 and 18.8 kgf/cm.sup.2 and percentage elongation after a 30-minute holding in physiological saline (which is a measure of its elasticity in a swollen state) varying from 21 to 880.
However, the compositions mentioned above are characterized by the fact that when in the form of dry films, they are brittle; therefore, the films should be placed in physiological saline within 10 to 15 minutes before use in order to impart adequate elasticity thereto.
On the other hand, higher elasticity of the films (characterized by their percentage elongation) results in a reduced strength of the material. Since the resorption period of the films exceeds the regeneration period of the soft tissues, the latter have no time enough to grow into the connective elements.
Besides since the material of the connective elements does not allow one to adjust its absorbability characterized by the degree of swelling, it cannot be used for treatment of suppurative skin lesions and operative wounds.
Known to be used commonly is also the material Debrisan (available from Pharmacea Co, Sweden) which is applicable for treatment of suppurative wounds (cf. the journal "Surgery", Meditsina Publishers, Moscow, No. 8, 1982, pp. 88-91 (in Russian). Debrisan appears as a white powder consisting of destran polymers; it features high degree of absorbability, i.e., 4 ml per gram of the agent. Debrisan is poured into the wound, then a moistened towelette is placed thereon and a piece of wax paper is put atop. Dressings are to be changed daily, the powder being removed by gauze balls and washed off with any suitable solution. Application of Debrisan contributes to debridement and drying of the wound and reduces the degree of edema. However, application of Debrisan is ineffective when the wound is invaded with blue pus bacillus, as well as in case of acute suppuration of the wound. In such a case administration of antibacterial drugs within the initial 2 or 3 days is more effective.
In addition, application of Debrisan to and its removal from deep wounds or fistular cavities is difficult.
DISCLOSURE OF THE INVENTION
It is an object of the present invention to provide a biocompatible material for treatment of tissular or organic defects that possess adjustable absorbability and resorption rate coordinated with tissue regeneration rate, and features higher elasticity in combination with adequately high strength.
The aforesaid object is accomplished due to the fact that a biocompatible material for treatment of tissular or organic defects based on a resorbable polymer, according to the invention, comprises a graft copolymer of alpha-cyanacrylate and polyacrylic acid having a molecular weight of 200,000 to 600,000 and obtained by the interreaction of alpha-cyanacrylate with polyacrylic acid in the presence of a cross-linking agent, the weight percentage ratio of the aforesaid components being as follows:
______________________________________ alpha-cyanacrylate 14 to 34
Polyacrylic acid having a molecular weight of
200,000 to 600,000 15 to 43
cross-linking agent 71 to 23
______________________________________
The biocompatible material as herein claimed comprises as alpha-cyanacrylate preferably ethyl-alpha-cyanacrylate, ethoxy-ethyl-alpha-cyanacrylate, butyl-alpha-cyanacry
REFERENCES:
patent: 3630194 (1971-12-01), Boardman
patent: 3667472 (1972-06-01), Halpern
patent: 3759264 (1973-09-01), Coover, Jr. et al.
patent: 4316457 (1982-02-01), Liegeois
patent: 4746544 (1988-05-01), Hogen-Esch
"Surgery" Meditsina Publishers 1982.
Akimova Alla Y.
Chigir Anatoly Nikolaevich
Davydov Anatoly B.
Egiev Valery N.
Iliina Anna I.
LandOfFree
Biocompatible material for treatment of tissular or organic defe does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biocompatible material for treatment of tissular or organic defe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible material for treatment of tissular or organic defe will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1993648