Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-04-26
2005-04-26
Wax, Robert A. (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S001210, C424S078080, C424S078170, C424S484000, C424S486000, C424S488000, C514S002600, C528S306000
Reexamination Certificate
active
06884778
ABSTRACT:
A new oligomer based on alternating fumaric acid and poly(ethylene glycol) (PEG) units is provided. The oligo(PEG fumarate) (OPF) may be functionalized by modification with a biocompatible organic group. Further, the OPF may be cross-linked using radical polymerization in the presence of either a chemical or photo initiator. A cross-linked OPF gel has a swelling behavior that is tunable dependent on the molecular weight of PEG. A cross-linkable PEG macromer, as exemplified by oligo(PEG fumarate), has unsaturated double bonds, for example in the fumaryl groups, along its macromolecular chain that allows for the preparation of hydrogels with tailored structure and properties.
REFERENCES:
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5527864 (1996-06-01), Suggs et al.
patent: 5573934 (1996-11-01), Hubbell et al.
patent: 5644005 (1997-07-01), Suggs et al.
patent: 5780426 (1998-07-01), Palladino et al.
patent: 5874500 (1999-02-01), Rhee et al.
patent: 5945457 (1999-08-01), Plate et al.
patent: 5986043 (1999-11-01), Hubbell et al.
patent: 5998362 (1999-12-01), Feng et al.
patent: 6028164 (2000-02-01), Loomis
patent: 6248363 (2001-06-01), Patel et al.
patent: 6306821 (2001-10-01), Mikos et al.
patent: 6596267 (2003-07-01), Hubbell et al.
Jo et al., “Modificationof Oligo(poly(ethylene glycol) fumarate) Macromer with a GRGD Peptide for the Preparation of Functionalized Polymer Networks,” Biomacromolecules 2001, 2, 255-261.*
PCT International Search Report for International App. No. PCT/US01/14910: Dated Aug. 2, 2001; (4 p.).
Jo Seongbong
Mikos Antonios G.
Conley & Rose, P.C.
Wax Robert A.
William Marsh Rice University
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