Biocompatible fluorescent imaging agents

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S009100, C424S009600, C548S449000, C546S276700, C546S269400, C540S575000

Reexamination Certificate

active

07947256

ABSTRACT:
This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.

REFERENCES:
patent: 4264694 (1981-04-01), Pu et al.
patent: 4981977 (1991-01-01), Southwick et al.
patent: 5073171 (1991-12-01), Eaton
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5569766 (1996-10-01), Waggoner et al.
patent: 5593658 (1997-01-01), Bogdanov et al.
patent: 5605809 (1997-02-01), Komoriya et al.
patent: 5627027 (1997-05-01), Waggoner
patent: 5808044 (1998-09-01), Brush et al.
patent: 5877310 (1999-03-01), Reddington et al.
patent: 6002003 (1999-12-01), Shen et al.
patent: 6004536 (1999-12-01), Leung et al.
patent: 6008373 (1999-12-01), Waggoner et al.
patent: 6027709 (2000-02-01), Little et al.
patent: 6043025 (2000-03-01), Minden et al.
patent: 6083485 (2000-07-01), Licha et al.
patent: 6083486 (2000-07-01), Weissleder et al.
patent: 6127134 (2000-10-01), Minden et al.
patent: 6130094 (2000-10-01), Waggoner et al.
patent: 6133445 (2000-10-01), Waggoner et al.
patent: 6136612 (2000-10-01), Della Ciana et al.
patent: 6248904 (2001-06-01), Zhang et al.
patent: 6258340 (2001-07-01), Licha et al.
patent: 6448008 (2002-09-01), Caputo et al.
patent: 6534041 (2003-03-01), Licha et al.
patent: 6592847 (2003-07-01), Weissleder et al.
patent: 6740755 (2004-05-01), Caputo et al.
patent: 6747159 (2004-06-01), Caputo et al.
patent: 6869593 (2005-03-01), Frangioni
patent: 6913743 (2005-07-01), Licha et al.
patent: 6926885 (2005-08-01), Licha et al.
patent: 7025949 (2006-04-01), Licha et al.
patent: 7374746 (2008-05-01), Frangioni
patent: 7445767 (2008-11-01), Licha et al.
patent: 7647091 (2010-01-01), Ntziachristos et al.
patent: 7655217 (2010-02-01), Licha et al.
patent: 2003/0044353 (2003-03-01), Weissleder et al.
patent: 2005/0169843 (2005-08-01), Weissleder et al.
patent: 2006/0099712 (2006-05-01), Gilman et al.
patent: 2006/0275775 (2006-12-01), Weissleder et al.
patent: 2008/0102036 (2008-05-01), Poss et al.
patent: 2008/0226562 (2008-09-01), Groves et al.
patent: 2008/0267883 (2008-10-01), Rajopadhye et al.
patent: 2008/0286207 (2008-11-01), Narayanan
patent: 2008/0312540 (2008-12-01), Ntziachristos
patent: 2008/0317676 (2008-12-01), Rajopadhye et al.
patent: 2009/0068115 (2009-03-01), Gaw et al.
patent: 2009/0123383 (2009-05-01), Frangioni
patent: 2009/0220430 (2009-09-01), Rajopadhye et al.
patent: 2010/0074847 (2010-03-01), Madden et al.
patent: 2010/0078576 (2010-04-01), Ntziachristos et al.
patent: 2010/0129293 (2010-05-01), Licha et al.
patent: 2010/0166659 (2010-07-01), Licha et al.
patent: 2010/0172841 (2010-07-01), Peterson et al.
patent: 2010/0189657 (2010-07-01), Weissleder et al.
patent: 0417941 (1991-03-01), None
patent: 0820057 (1998-01-01), None
patent: 1065250 (2001-01-01), None
patent: 1090961 (2001-04-01), None
patent: 1219626 (2002-07-01), None
patent: 10071766 (1998-03-01), None
patent: WO-9740104 (1997-10-01), None
patent: WO-9931181 (1999-06-01), None
patent: WO-9951702 (1999-10-01), None
patent: WO-00/16810 (2000-03-01), None
patent: WO-0121624 (2001-03-01), None
patent: WO-2007/028163 (2007-03-01), None
patent: WO-2009114776 (2009-09-01), None
Becker et al. (2000) “Macromolecular Contrast Agents for Optical Imaging of Tumors: Comparison of Indotricarbocyanine-labeled Human Serum Albumin and Transferrin,”Photochom. Photobiol. 72:234-241.
Brasseur et al. (1999) “Receptor-Mediated Targeting of Phthalocyanines to Macrophages via Covalent Coupling to Native or Maleylated Bovine Serum Albumin,”Photochem. Photobiol. 69:345-353.
Gatter et al. (1983) “Transferrin Receptors in Human Tissues: Their Distribution and Possible Clinincal Relevance,”J. Clin. Path. 36:539-545.
Hamblin et al. (1994) “Photosensitizer Targeting in Photodynamic Therapy. I. Conjugates of Haematoporphyrin with Albumin and Transferrin,”J. Photochem Photobiol. B. 26(1):45-56.
Hansch et al. (2004) “Diagnosis of Arthritis Using Near-Infrared Fluorochrome Cy5.5,”Investigative Radiology39(10):626-632.
Kremer et al. (2000) “Laser-Induced Fluorescence Detection of Malignant Gliomas Using Fluorescein-labeled Serum Albumin: Experimental and Preliminary Clinical Results,”Neurol. Res. 22(5):481-489.
Montet et al. (2006) “An Albumin-Activated Far-Red Fluorochrome for In Vivo Imaging,”Chem Med Chem1(1):66-69.
Parmelee et al. (1997) “Preclinical Evaluation of the Pharmokinetics, Biodistribution and Elimination of MS-325, a Blood Pool Agent for Magnetic Imaging Resonance,”Investigative Radiology32(12):741-747.
Rennen et al. (2001) “The Effect of Molecular Weight on Nonspeciific Accumulation of (99m) T-Labeled Proteins in Inflammatory Foci,”Nucl. Med. Biol. 28(4):401-408.
Schilling et al. (1992) “Design of Compounds Having Enhanced Tumour Uptake, Using Serum Albumin as a Carrier—Part II. In Vivo Studies,”Int. J. Rad. Appl. Instrum. B. 19(6):685-695.
Tromberg et al. (1997) “Non-invasive measurements of breast tissue optical properties using frequency-domain photo migration,”Phil. Trans. R. Soc. London B352:661-668.
Wang et al. (2001) “Amplified Delivery of Indium-111 to EGFR-Positive Human Breast Cancer Cells,”Nucl. Med. Biol. 28:895-902.
Williams et al. (1993) “Comparison of Covalent and Noncovalent Labeling with Near-Infrared Dyes for the High-Performance Liquid Chromatographic Determination of Human Serum Albumin,”Anal. Chem. 65:601-605.
Wyatt (1997) “Cerebral oxygenation and haemodynamics in the fetus and newborn infant,”Phil. Trans. R. Soc. London B352:697-700.
Ciernik et al. (1972) “New synthesis of neocyanine dyes containing three heterocycles,”Collection of Czechoslovak Chemical Communications37(11):3800-3807. Abstract only.
Ciernik et al. (1972) “New pentamethinecyanine dyes,”Collection of Czechoslovak Chemical Communications37(8):2771-2778. Abstract only.
International Search Report and Written Opinion for International Patent Application No. PCT/US2006/034604, dated Jan. 31, 2007, 11 pages.
Bredereck et al. (1970) “Syntheses in the heterocyclic series. XIV. Formylation of 4-methylpyrimidine and reactions of 2-(4-pyrimidinyl)malonaldehyde,”Justus Liebigs Annalen der Chemie737:46-52. Abstract only.
Ernst et al. (1989) “Cyanine Dye Labelling Reagents for Sulphydryl Groups”,Cytometry, 10:3-10.
Ficken, (1971) “The Chemistry of Synthetic Dyes”, vol. 4, K. Venkataraman Ed., Academic Press, New York, p. 211-223.
Fry (1977) “Rodd's Chemistry of Carbon Compounds”, “Cyanine Dyes and Related Compounds”, Elsevier, Amsterdam. vol. IVb, Chapter 15, p. 369-424.
International Search Report and Written Opinion for International Patent Application No. PCT/US2006/034260, dated Jan. 31, 2007, 9 pages.
Lindsey et al. (1989) Visible Light Harvesting in Covalently-Linked Porphyrin Cyanine Dyes,Tetrahedron, 45:4845-4866.
Mujumdar et al. (1989) “Cyanine Dye Labelling Reagents Containing Isothiocyanate Groups”,Cytometry, 10:11-19.
Mujumdar et al. (1993) “Cyanine Dye Labelling Reagents: Sulfoindocyanine Succinimidyl Esters”,Bioconjugate Chemistry, 4:105-111.
Mujumdar et al. (1996) “Cyanine Labelling Reagents: sulfobenzoindocyanine succinimidyl esters”,Bioconjugate Chemistry, 7:356-362.
Ozmen et al. (2000) “Infrared fluorescence sensing of submicromolar calcium: pushing the limits of photoinduced electron transfer,”Tetrahedron Letters41:9185-9188.
Sun et al. (2006) “‘Clickable’ Nanoparticles for Targeted Imaging,”Molecular Imaging5(2):122-128.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Biocompatible fluorescent imaging agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible fluorescent imaging agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible fluorescent imaging agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2681831

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.