Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Miscellaneous
Patent
1989-05-05
1990-12-25
Green, Randall L.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Miscellaneous
623 1, 623 6, 623 11, 435176, 435180, 351160H, A61F 254, A61F 216
Patent
active
049799592
ABSTRACT:
The biocompatibility of biomaterials having solid surfaces is improved through coating the same with biocompatible agents where the biocompatible agents are covalently bonded to the solid surface via a chemical linking moiety. The method for modifying the solid surface to improve biocompatibility employs molecules of a biocompatible agent and a chemical linking moiety possessing a photochemically reactive group capable upon activation of covalently bonding to the solid surface and possessing a different reactive group as capable upon activation of covalently bonding to separate molecules of the biocompatible agent. One of the groups is unresponsive to activation by a stimulus to which the other group is responsive. The method comprises applying stimulus to sequentially activate the groups and covalently bind the different reactive group of the linking moiety to the molecules of the biocompatible agent and to photochemically covalently bind the linking moiety to the solid surface with a sufficient population density to enable the molecules of the biocompatible agent to effectively shield the solid surface and to provide a biocompatible surface.
REFERENCES:
patent: 3808113 (1974-04-01), Okamura et al.
patent: 3910296 (1975-10-01), Karageozian et al.
patent: 3955012 (1976-05-01), Okamura et al.
patent: 3959078 (1976-05-01), Guire
patent: 4007089 (1977-02-01), Smith, III
patent: 4160698 (1979-07-01), Miyairi et al.
patent: 4240163 (1980-12-01), Galin
patent: 4378224 (1983-03-01), Nimni et al.
patent: 4378435 (1983-03-01), Takagi et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4500676 (1985-02-01), Balazs
patent: 4526714 (1985-07-01), Feijen et al.
patent: 4526909 (1985-07-01), Urist
patent: 4530974 (1985-07-01), Munro et al.
patent: 4536179 (1985-08-01), Anderson et al.
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4715858 (1987-12-01), Lindstrom
patent: 4716122 (1987-12-01), Scheefers
patent: 4828563 (1989-05-01), Muller-Lierheim
P. Guire, et al., "Photochemical Coupling of Enzymes to Mammalian Cells", 1977, pp. 131-141.
P. Guire, et al., "Stepwise-Crosslinking Reagents for Photocoupling of Enzymes and Lectins to Mammalian Cells", 1977, pp. 1051-1054.
P. Guire, "Stepwise Thermophotochemical Crosslinking for Enzyme Stabilization and Immobilization", 1978, pp. 63-70.
P. Guire, "Photochemical Immobilization of Enzymes and Other Biochemicals", (ed. Klaus Mosbach 1976), pp. 280-288.
Bauman Mary P.
Bio-Metric Systems, Inc.
Green Randall L.
Haller James R.
Kaihoi Gregory P.
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