Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1997-05-23
1999-03-23
Azpuru, Carlos A..
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424435, 424447, 424499, 424501, 424502, A61F 1302, A61L 1516, A61K 950
Patent
active
058856099
ABSTRACT:
Articles of manufacture and methods of making the same, comprising a cationic polymer which has been surface-modified by a method comprising the steps of swelling a cationic polymer in a medium having a pH value <7; applying a surface-modifying agent to the cationic polymer to form a mixture; and adjusting the pH of the mixture to a value .gtoreq.7. A preferred embodiment relates to semipermeable membranes suitable for hemodialysis made from chitosan, the surface of which has been modified by anionic polysaccharides such as dextran or heparin, or anionic polyoxyalkylenes such as acid-modified polyethylene glycol, to improve blood compatibility.
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Azpuru Carlos A..
Northeastern University
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