Biocompatible anion exchange materials

Details Biocompatible anion exchange materials Biocompatible anion exchange materials

1994-09-30

1997-07-15

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424 7817, B01D 1508

Patent

active

056480709

ABSTRACT:
Biocompatible anion exchange materials are provided comprising a support having a quaternary amine moiety and a polyethylene oxide (PEO) moiety having between about 10 and about 200 repeating units covalently bonded thereto, such that said quaternary amine and polyethylene oxide moieties are substantially homogeneously distributed on said support. These anion exchange materials are useful for removing negatively charged species such as heparin from blood and other body fluids without significant removal of platelets. Methods of making and using these materials are also provided.

REFERENCES:
patent: 3472840 (1969-10-01), Stone et al.
patent: 4048064 (1977-09-01), Clark
patent: 4070287 (1978-01-01), Wiegand et al.
patent: 4355117 (1982-10-01), Antrim et al.
patent: 4373023 (1983-02-01), Langer
patent: 4663163 (1987-05-01), Hou et al.
patent: 4678468 (1987-07-01), Hiroyoshi
patent: 4678660 (1987-07-01), McGary et al.
patent: 4690973 (1987-09-01), Noishiki et al.
patent: 4800016 (1989-01-01), Yang
patent: 4810567 (1989-03-01), Calcaterra et al.
patent: 4936998 (1990-06-01), Nishimura et al.
patent: 5151192 (1992-09-01), Matkovich et al.
patent: 5354472 (1994-10-01), Voorhees et al.
07/562,009 Aug. 2, 1989, Maddock.
Andrade et al., "Surfaces and Blood Compatibility" Trans. Am. Soc. Artif. Intern. Organs (1987) 33: 75-84.
Benerito, R.R. et al., "Preparation and Properties of Quaternary Cellulose Anion Exchanges," Anal. Chem. (1965) 37:1693-1699.
Brian, Ben F. III, Ph.D. Thesis (1991) entitled "Augmented Hemoperfusion for Hyperbilirubinemia".
Brian, Ben et al., Confidential disclosure of invention entitled "A Method for Producing Whole Blood Compatible Anion Exchange Materials" dated Feb. 12, 1991.
Cipoletti, J.J. et al., "Resin Technology in Medicine," Sorbents and Their Clinical Applications (Giordana ed.), Academic Press, New York, 1980, pp. 221-248.
Citovicky, P. et al., "Epoxy Groups on Grafted Polypropylene," Die Angewandte Makromolekulare Chemie (1989) 171:153-164.
Han, D.K. et al., "Preparation and surface characterization of PEO-grafted and heparin-immobilized polyurethanes," J. Biomed. Mater. Res.: Applied Biomaterials, (1989) 23(A1):87-104.
Hou et al., "A Method for Extracorporeal Heparin Removal from Blood by Affinity Chromatography," Art. Organs (1990) 14(6):436-442.
Hou, L.C. and Mandaro, R.M., "Bioseparation by Ion Exchange Cartridge Chromatography," BioTechniques, 358-366.
"IDE Sought for Heparin Removal Device", BBI Newsletter (Mar. 1994) 17(3):56-57.
Ito, H. et al., "Formatin of Polyelectrolyte Complexes between Cellulose Derivatives and Their Blood Compatibility," J. App. Polymer Sci. (1986) 31:2491-2500.
Matsuda, K. et al., "Experimental Study on the Adsorption of Excess Heparin with Anion Exchange Resin Fiber," Art. Organs (1989) 13(6):504-507.
Mori, Y. et al., "A New Antithrombogenic Material with Long Polyethyleneoxide Chains," Trans Am. Soc. Artif. Intern. Organs (1982) 28:459-463.
Shechter, L. and Wynstra, J., "Glycidyl Ether Reactions with Alcohols, Phenols, Carboxylic Acids, and Acid Anhydrides," Industrial and Engineering Chemistry, (1956) 48(1):86-93.
Shechter, L. et al., "Glycidyl Ether Reactions with Amines," Industrial and Engineering Chemistry, (1956) 48(1):94-97.
Sideman, S. et al., "Resin Hemoperfusion for Unconjugated Bilirubin Removal," Contr. Nephrol. (Karger, Basel 1982) 29:90-100.
Soignet, D.M. et al., "Comparison of Properties of Anion-Exchange Cottons in Fabric Form", Textile Res. J. (1966) 978-989.
Tanaka, H. and Odberg, L., "Preparation of Cationic Polyacrylamides by a Modified Hofmann Reaction: Fluorescent Labeling of Cationic Polyacrylamides," J. Polymer Sci: Part A: Polymer Chemistry (1989) 27:4329-4339.
Wilson, "How Surface-Bound Drugs Inhibit Thrombus Formation,", Drug. Dev. Res. (1990) 21:39-92.

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