Coating processes – Medical or dental purpose product; parts; subcombinations;... – Particulate or unit-dosage-article base
Patent
1993-01-19
1994-05-03
Beck, Shrive
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Particulate or unit-dosage-article base
435180, 435181, A61F 254
Patent
active
053086414
ABSTRACT:
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
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Cahalan Linda
Cahalan Patrick T.
Hendriks Marc
Verhoeven Michel
Beck Shrive
Dudash Diana
Latham Daniel W.
Medtronic Inc.
Patton Harold R.
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