Stock material or miscellaneous articles – Surface property or characteristic of web – sheet or block
Patent
1994-02-09
1995-05-16
Seidleck, James J.
Stock material or miscellaneous articles
Surface property or characteristic of web, sheet or block
4284235, 4284735, 428525, 435180, 435181, A61F 201
Patent
active
054159385
ABSTRACT:
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
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Cahalan Linda
Cahalan Patrick T.
Hendriks Marc
Verhoeven Michel
Delaney Patrick R.
Latham Daniel W.
Medtronic Inc.
Patton Harold R.
Seidleck James J.
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