Biocompatability of solid surfaces

Details Biocompatability of solid surfaces Biocompatability of solid surfaces

1995-04-27

1997-12-30

Tsang, Cecilia J.

Stock material or miscellaneous articles

Surface property or characteristic of web, sheet or block

4284111, 4284235, 4284735, 428525, 435180, 435181, A61F 201

Patent

active

057028184

ABSTRACT:
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.

REFERENCES:
patent: 4565740 (1986-01-01), Golander et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4786556 (1988-11-01), Hu et al.
patent: 5049403 (1991-09-01), Larm et al.

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