Biocidal compositions

Details Biocidal compositions Biocidal compositions

1996-08-28

2001-11-27

Levy, Neil S. (Department: 1617)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

C514S568000

Reexamination Certificate

active

06322807

ABSTRACT:

This invention relates to the use of compositions comprising benzoic acid for use as a medicament for animals, especially pigs, at the same time promoting growth thereof and improving the digestibility of amino acids fed to such animals.
It is known from our own prior published EP-A-0683985 that animal feed compositions comprising benzoic acid or salts thereof can be used to minimise the emission of odoriferous ammonia from organic wastes, especially animal excrements and manure.
It has now been found that in addition to the above function, benzoic acid can be used instead of relatively expensive antibiotics for such animals and furthermore, such acid/salts have the advantage of being able to promote growth, decrease feed conversion and improve digestibility of amino acids in animal feeds.
Accordingly, the present invention is a composition comprising benzoic acid or a derivative of benzoic acid capable of giving rise to free benzoic acid in vivo for use as a medicament for animals, wherein said acid/salt functions as an antibiotic, promotes growth, decreases feed conversion and improves digestibility of amino acids administered in animal feeds.
Benzoic acid or a derivative thereof capable of giving rise to benzoic acid in vivo may be administered to the animals as a component of a composition which is conventionally fed to animals. Thus, benzoic acid and derivatives thereof may be suitably administered to the animals as a component of the animal feed or in their drinking water. Specific examples of derivatives of benzoic acid which can give rise to benzoic acid in vivo include salts of benzoic acid such as eg the alkali metal-alkaline earth metal- and ammonium benzoates.
The amount of benzoic acid or a derivative thereof administered to the animal is suitably such that it is sufficient to prevent/cure any infection in the animal in its capacity as a biocide. Such an amount is suitably in the range from 0.001-5% based on the total weight of each feed fed to the animal. This amount may, however, be higher if the function of benzoic acid or a derivative thereof is no only to act as a biocide but also to control the pH of the animal excreta fed on such a diet in order to suppress the emission of ammonia from the excreta. Such higher amounts are suitably limited to a maximum of about 10% based on the total animal feed composition.
A typical formulation for an animal feed composition is shown in Table 1 below in which all the amounts shown in % by weight were fed to pigs:
TABLE 1
Composition
Control II
ExampIe 1
Meat meal (58% Crude protein)
3.20
3.20
Molasses
5.00
5.00
Wheat
5.90
5.90
Soybean meal (45% Crude
15.1
15.1
protein)
Tapioca (66% starch)
36.5
35.5
Wheat middlings
15
15
Animal fat
3.3
3.3
Limestone
0.74
0.74
Lysine hydrochloride (98%)
0.06
0.06
Vitamin premix
0.5
0.5
Trace minerals
0.5
0.5
Sunflower meal
12.2
12.2
Ammonium chloride
2
2
Ammonium benzoate
—
1
Thus, benzoic acid or a derivative thereof may be used in combination with conventional ingredients present in an animal feed composition (diet) such as calcium carbonates, electrolytes such as eg ammonium chloride, proteins such as soya bean meal, wheat, starch, sunflower meal, corn, meat and bone meal, amino acids, animal fat, vitamins and trace minerals.
In such a composition, the ratio of the electrolyte to the benzoic acid or a derivative thereof is suitably in the range from 0.5:1 to 5:1 w/w, preferably from 1.5:1 to 3:1 w/w.
Benzoic acid or a derivative thereof is particularly effective as a medicament for animals such as poultry, pigs or cattle, especially pigs.
The present invention is further illustrated with reference to the following Examples:


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CA abstract, 104:50274 (Deetz, L.E. et al.), 1985.*
Proceedings 1993 Cornell Nutrition Conference for Feed Manufactures, 1993, 55th Ithaca, N.Y. pp. 130-143.
Keshavaraz K.; et al, ‘The Effect of Acidogenic Salts on Acid-Base Balance and Eggshell Quality in Laying Hens’.
Keshavarz, Poultry Science, vol. 70 (1991) pp. 1723-1731.
Keshavarz, Proc. 1993, Cornell Nutrition Conf., pp. 19-32.
Abstract of JP 07228533, Dialog File: Derwent WPI.
Abstract of JP 06298641, Dialog File: Derwent WPI.

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