Biochip manufacturing method and biochip manufacturing device

Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer

Reexamination Certificate

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Details

C422S547000, C422S551000, C422S552000, C422S553000, C435S006120, C435S283100, C435S287200, C436S050000, C436S047000

Reexamination Certificate

active

07960183

ABSTRACT:
Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, having the steps of filling a retention liquid which separates without getting mixed with the sample liquid into the liquid housing unit, the passage, and the cavity; injecting the sample liquid into the liquid housing unit; moving the sample liquid from the liquid housing unit to the cavity by discharging the retention liquid from the nozzle hole; stopping the discharge of the retention liquid at the moving step upon detecting with a sensor that the sample liquid reached a position adjacent to the nozzle hole; and delivering the sample liquid as droplets onto the object by discharging the sample liquid from the nozzle hole.

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Collins, John et al., “Microfluidic Flow Transducer Based on the Measurement of Electrical Admittance”, Miniaturisation for Chemistry, Biology & Bioengineering, Lab Chip, 2004, 4, (Nov. 11, 2003), pp. 7-10.

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