Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1981-09-30
1984-03-20
Nafe, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
210927, 435 69, 435176, 435177, 435180, 435181, 435229, 435288, C12N 1110, C12N 1102, C12N 1106, C12M 140
Patent
active
044381980
ABSTRACT:
A biochemically active matrix for use in a bio-artificial organ is disclosed. The biochemically active matrix has an enzyme covalently bonded to a matrix of organochemically cross-linked fibrin. The matrix may be suspended in a medium of agarose which irreversibly solidifies below 37.degree. C. The bio-artificial organ is useful for extracorporeal treatment of blood to remove excess substrate from the blood. .
REFERENCES:
patent: 3639558 (1972-02-01), Csizmas et al.
Dillon et al., Enzyme Immobilization on Fibrin, Chemical Abstracts, vol. 84:117768g, 1976, (p. 210).
Jackson et al., A New Extracorporeal Reactor-Dialyzer for Enzyme Therapy Using Immobilized L-Asparaginase, The Journal of Pharmacobogy and Experimental Therapeutics, vol. 209, No. 2, 1979, (pp. 271-274).
Zaborsky, O., Immobilized Enzymes, CRC Press, Cleveland, Ohio, 1973, (pp. 135-144).
Dillon et al., Enzyme Immobilization of Fibrin, Biotechnology and Bioengineering, vol. XVIII, 1976, (pp. 133-139).
Nafe David M.
Trimedyne, Inc.
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