Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Glycoproteins
Reexamination Certificate
2008-01-01
2008-01-01
Spector, Lorraine (Department: 1647)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Glycoproteins
C435S007100, C530S399000
Reexamination Certificate
active
10862791
ABSTRACT:
The invention provides prenatal screening methods for Down's syndrome. Specifically, the methods of the invention comprise determining the amount of hyperglycosylated human chorionic gonadotropin (hCG) charge isoforms in a biological sample from a pregnant woman and comparing the amount of highly acidic and less acidic isoforms with those found in a sample taken from a pregnant woman carrying a normal fetus. The methods of the invention can be employed during any stage of pregnancy.
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patent: 5324667 (1994-06-01), Macri
patent: 6025149 (2000-02-01), Cuckle et al.
patent: 6429018 (2002-08-01), Cole et al.
patent: 6500627 (2002-12-01), O'Connor et al.
patent: 2003/0027234 (2003-02-01), Pandian et al.
patent: WO 98/10282 (1998-03-01), None
Cole et al., Prenat. Diagn 1997, vol. 17, pp. 1188-1190.
Cole et al., Prenat. Diagn 1999, vol. 19, pp. 351-359.
Sutton et al., Prenat Diagn. 2004, vol. 24(3): pp. 194-197.
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Cole, Laurence A. et al., “Hyperglycosylated Human Chorionic Gonadotropin (Invasive Trophoblast Antigen) Immunoassay: A New Basis for Gestational Down Syndrome Screening,” Clin. Chem., 1999, 45:12, 2109-19.
ABSTRACT: Cuckle, H. S. et al., “Maternal Urine Hyperglycosylated hCG in Pregnancies With Down Syndrome,” Prenat. Diag., Oct. 1999, 19(10), 918-20.
ABSTRACT: Bahado-Singh, R. et al., “Urine Hyperglycosylated hCG Plus Ultrasound Biometry for Detection of Down Syndrome in the Second Trimester in a High-risk Population,” Obstet. Gynecol., Jun. 2000, 95(6, pt. 1), 889-94.
ABSTRACT: Bahado-Singh, R. et al., “Comparison of Urinary Hyperglycosylated Human Chorionic Gonadotropin Concentration with the Serum Triple Screen for Down Syndrome Detection in High-risk Pregnancies,” Am. J. Obstet. Gynecol., Nov. 2000, 183(5), 1114-18.
Cole Laurence A
Riley Jaime M
Coleman Henry D
Sapone William J
Spector Lorraine
STC. UNM
Sudal R. Neil
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