Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-12-06
2005-12-06
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S422000, C424S423000, C424S600000, C424S601000, C424S602000
Reexamination Certificate
active
06972130
ABSTRACT:
The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.
REFERENCES:
patent: 4157378 (1979-06-01), Tomlinson et al.
patent: 4346709 (1982-08-01), Schmitt
patent: 4347234 (1982-08-01), Wahlig et al.
patent: 4429691 (1984-02-01), Niwa et al.
patent: 4612053 (1986-09-01), Brown et al.
patent: 4684673 (1987-08-01), Adachi
patent: 4737411 (1988-04-01), Graves, Jr. et al.
patent: 4842603 (1989-06-01), Draenert
patent: 4849193 (1989-07-01), Palmer et al.
patent: 4880610 (1989-11-01), Constantz
patent: RE33161 (1990-02-01), Brown et al.
patent: 4917702 (1990-04-01), Scheicher et al.
patent: RE33221 (1990-05-01), Brown et al.
patent: 4938938 (1990-07-01), Ewers et al.
patent: 4959104 (1990-09-01), Lino et al.
patent: 5034059 (1991-07-01), Constantz
patent: 5037639 (1991-08-01), Tung
patent: 5047031 (1991-09-01), Constantz
patent: 5053212 (1991-10-01), Constantz et al.
patent: 5085861 (1992-02-01), Gerhart et al.
patent: 5129905 (1992-07-01), Constantz
patent: 5149368 (1992-09-01), Liu et al.
patent: 5152836 (1992-10-01), Hirano et al.
patent: 5164187 (1992-11-01), Constantz et al.
patent: 5178845 (1993-01-01), Constantz et al.
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5262166 (1993-11-01), Liu et al.
patent: 5279831 (1994-01-01), Constantz et al.
patent: 5281265 (1994-01-01), Liu
patent: 5286763 (1994-02-01), Gerhart et al.
patent: 5336264 (1994-08-01), Constanz et al.
patent: 5342441 (1994-08-01), Mandai et al.
patent: 5352715 (1994-10-01), Wallace et al.
patent: 5399665 (1995-03-01), Barrera et al.
patent: 5470803 (1995-11-01), Bonfield et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5496399 (1996-03-01), Ison et al.
patent: 5514378 (1996-05-01), Mikos et al.
patent: 5516532 (1996-05-01), Atala et al.
patent: 5522893 (1996-06-01), Chow et al.
patent: 5525148 (1996-06-01), Chow et al.
patent: 5542973 (1996-08-01), Chow et al.
patent: 5545254 (1996-08-01), Chow et al.
patent: 5565502 (1996-10-01), Glimcher et al.
patent: 5605713 (1997-02-01), Boltong
patent: 5665120 (1997-09-01), Ohtsuka et al.
patent: 5691397 (1997-11-01), Glimcher et al.
patent: 5700289 (1997-12-01), Breitbart et al.
patent: 6132463 (2000-10-01), Lee et al.
patent: 0 268 463 (1988-05-01), None
patent: 0347028 (1989-11-01), None
patent: 0664133 (1995-07-01), None
patent: 63111875 (1988-05-01), None
patent: 63170205 (1988-07-01), None
patent: 2-182261 (1990-07-01), None
patent: 5-305134 (1993-11-01), None
patent: 06228011 (1994-08-01), None
patent: 7277712 (1995-10-01), None
patent: WO 92/02453 (1991-07-01), None
patent: WO 92/00109 (1992-01-01), None
patent: WO 94/04657 (1993-08-01), None
patent: WO 94/02412 (1994-02-01), None
patent: WO 94/20064 (1994-09-01), None
patent: WO 95/08319 (1994-09-01), None
patent: WO 96/36562 (1996-05-01), None
patent: WO 97/17285 (1996-11-01), None
Aoki, “Science and medical applications of hydroxyapatite”,JAAS, 11-15, 1991.
Appel et al., “Oncologic, Endocrine & Metabolic—Overview—Recent advances in implants for bone growth promotion”,Exp. Opin. Ther. Patents,4(12):1461-1469, 1994.
Atala et al., “Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux”,J. Urol.,150:745, 1993.
Athanasou et al., “Current Concepts Review: Cellular Biology of Bone Resorbing Cells”,J. Bone and Joint Surg.,78-A:1096-1112, 1996.
Barton, et al., “Surface and bulk properties of amorphous calcium phosphate” Colloid Interface Sci. [Proc. Int. Conf.], 50th371 (1976) [CA 87:73954v].
Benghuzzi et al., “Alcap ceramic implantable devices and the effect of surface area on the delivery of various steroid hormones”, Abstract, Eighth Southern Biomedical Engineering Conference Richmond, VA, Oct. 15-16, 1989; Biomater. Artif. Cells Artif. Organs, 17:464, 1989.
Benghuzzi et al., “Controlled release of hydrophilic compounds by resorbable and biodegradable ceramic drug delivery devices”, Biomed, Sci. Instrum., 28:179-182, 1992.
Benghuzzi et al., “Resorbable and biogradable ceramics as drug delivery systems”, Abstract,Eighth Southern Biomedical Engineering Conference Richmond, VA, Oct. 15-16, 1989; Biomater. Artif. Cells Artif. Organs,17:463, 1989.
Benghuzzi, et al., “Long-term delivery of Danazol by biogradable ceramic devices”, Abstract,Eighth Southern Biomedical Engineering Conference Richmond, VA, Oct. 15-16, 1989; Biomater. Artif. Cells Artif. Organs,17:465, 1989.
Besic et al., “Electron probe microanalysis of noncarious enamel and dentin and calcified tissues in mottled teeth”,J. Dent. Res.,48:131, (Jan.-Feb., 1969).
Blumenthal et al., “Effect of Preparation Conditions on the Properties and Transformation of Amorphous Calcium Phosphate”,Mat Res. Bull.,7(11):1181 (Nov. 1972).
Boskey, Adele, “Matrix Proteins and Mineralization: An Overview”,Connect Tissue Res.,35:(1-4):357-63, 1996.
Cannon et al., “Continuous delivery of azidothymidine by hydroxyapatite or tricalcium phosphate ceramics”,Biomed. Sci. Instrm.31:159-164, 1995.
Chu et al., “Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study”,J. Biomed. Mater. Res.,29:1147, 1995.
Chung, et al., “Biological effects of drug-loaded biodegradable membranes for guided bone regeneration”J. Periodont. Res.,32:172-175. 1997.
Clarke, et al., “Non-sterodial Anti-Inflammatory Drug Induced Differentiation of Bone Marrow Stromal Cells” 43rdAnnual Meeting, Ortho Res. Soc., San Francisco, CA, 574. Feb. 9-13, 1997.
Constantz et al., “Skeletal repair by in situ formation of the mineral phase of bone”,Sci.,267:1976, 1995.
Dennissen, et al., “New-shaped hysroxyapatite implants for release of agents modulating periodontal-like tissues”J. Periodont. Res.,32:40-46, 1997.
Driessens et al., “Calcium Phosphate bone Cements”Encycl. Hndbk. Of Biomat. And Bioeng.,Wise (EDS) NY, Marcel Dekker, 1995.
Ducheyne et al., “Bioceramic Composites”, Chapter 15 from “An Introduction to Bioceramics, Advanced Series in Ceramics”, vol. I.
Eanes et al., “Intermediate states in the precipitation of hydroxyapatite”,Nature,208:365-367, Oct. 23, 1965.
Eanes et al. “Intermediate phases in the basic solution preparation of alkaline earth phosphates”Calcif. Tiss. Res.,2(1):38 (1968)[CA 69:110373f].
Eanes et al., “Thermochemical studies on amorphous calcium phosphate”,Calc. Tiss. Res.,5:133, 1970.
Etex (D. Knaack) “Endothermically Setting Calcium Phosphate Bone Substitute” Orthop. Cong. Aug. 20-22, 1997, Boston, MA.
Etex (Knaack et al) “Novel Fully Resorbable Calcium Phosphate Bone Substitute” 1997ASBMR Abstract,vol. 12, Supplement 1:202 Aug., 1997.
Etex (Knaack et al) “A Fully Resorbable Calcium Phosphate Bone Substitute”Portland Bone Symp.,1997.
Fabbri et al., “Hydroxyapatite-based porous aggregates: physico-chemical nature, s
Aiolova Maria
Lee Dosuk D.
Rey Christian
Tofighi Aliassghar
Clark Paul T.
Clark & Elbing LLP
Dodson Shelley A.
Etex Corporation
George Konata M.
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