Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Reexamination Certificate
2008-04-03
2010-06-01
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
C435S170000, C435S189000, C435S195000, C435S219000, C435S196000, C435S255100
Reexamination Certificate
active
07727750
ABSTRACT:
The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino-[5-(1-hydroxy-2-hydroxy or halogen-ethyl)]-pyrazine derivatives of the formulawherein R is lower alkylcarbonyl or an amino protecting group and R1is hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.
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Hanlon Steven Paul
Iding Hans
Kupfer Ernst
Radinov Roumen Nikolaev
Shu Lianhe
Hanley Susan
Hoffman-La Roche Inc.
Johnston George W.
Megerditchian Samuel H.
Saucier Sandra
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