Bioassay for transforming genes and genes detected thereby

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435320, 935 9, 935 27, C07H 2100, C12N 100, C12N 1500

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active

048661660

ABSTRACT:
A sensitive bioassay for transforming genes based on the tumorigenicity of cotransfected NIH3T3 cells in nude mice is disclosed. Genes mcf2 and mcf3 have been detected in tissue breast cancer using this assay.

REFERENCES:
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patent: 4535058 (1985-08-01), Weinberg et al.
Fasano, O. et al., Molecular and Cellular Biology, vol. 4, No. 9, Sep. 1984, pp. 1695-1705.
Perucho, M. et al, Cell, vol. 27, Dec. 1981, pp. 467-476.
Blair, D. G. et al, Science, vol. 218, Dec. 1982, pp. 1122-1125.

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