Bioassay for thrombogenesis and rabbit model

Details Bioassay for thrombogenesis and rabbit model Bioassay for thrombogenesis and rabbit model

1993-09-07

1997-10-07

Stone, Jacqueline M.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG5, 424 9, 435 13, C12N 500, A61K 5100, G01N 3348

Patent

active

056750587

ABSTRACT:
An in vivo assay for determining the potential thrombogenic activity of a test compound entails pre-treating an animal with both a hepatoxin and either a bacterial agent (whole bacteria or bacterial toxins, including endotoxins) or a bacterial agent-induced cytokine, which pre-treatment enhances sensitivity to thrombogenic substances. The sensitized animal can be used in identifying a thrombogenic substance even when it is a weak potentiator of thrombogenesis, and in detecting smaller amounts of a strong potentiator.

REFERENCES:
Wessler et al (1959) J. Applied Physio. 14, 943-946.
Jones et al (1974) Infection and Immunity 10, 1343-1349.
Cybulsky et al (1988) Lab. Invest. 58, 365-378.
Fareed et al. Seminars in Thrombosis and Hemostasis 11(2): 155-75 (1985).
Galanos et al. PNAS U.S.A. 76 (11): 5939-43 (1979).

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