Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving luciferase
Patent
1997-03-10
1998-12-29
Elliott, George C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving luciferase
435354, 549359, C12Q 166, C12N 518, C07O31902
Patent
active
058540105
ABSTRACT:
A recombinant cell line deposited at the American Type Culture Collection under ATCC accession number CRL-12286, also known as the mouse H1L1.1 cell line, has been made by using genetic engineering techniques for inserting dioxin responsive elements upstream of a luciferase reporter gene, and then, transfecting the resultant recombinant expression plasmid, identified as pGudLuc1.1, into mouse hepatoma cells. The mouse H1L1.1 cell line is useful in a method for the quantitative analysis of polyaromatic hydrocarbons in samples.
REFERENCES:
patent: 4238472 (1980-12-01), Albro et al.
patent: 4798807 (1989-01-01), Vanderlaan et al.
patent: 4865972 (1989-09-01), Hunter
patent: 5128244 (1992-07-01), Poland et al.
patent: 5378822 (1995-01-01), Bradfield et al.
patent: 5429925 (1995-07-01), Vanderlaan et al.
patent: 5476953 (1995-12-01), Clardy et al.
patent: 5484709 (1996-01-01), Friedman et al.
patent: 5496703 (1996-03-01), Babish et al.
Garrison et al. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fund. and Appl. Toxicol. vol. 30 pp. 194-203, 1996.
El-Fouly et al. Production of a novel recombinant cell line for use as a bioassay system for detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemixals. Environ. Toxicol. and Chem. vol. 13 pp. 1581-1588, 1994.
Aarts et al. Species-specific antagonism of Ah receptor action by 2,2',5,5'-tetrachloro-and 2,2'3,3',4,4' hexachlorobiphenyl. Eur. J. Pharmacol. Environ. Toxicol. and Pharmacol. Sect. 293 pp. 463-474, 1995.
Klein-Hitpass et al., "A 13 bp Palindrome is a Functional Estrogen Responsive Element and Interacts Specifically with Estrogen Receptor", Nucleic Acids Research, vol. 16, No. 2, (1988) pp. 647-663.
Tanabe et al., "Highly Toxic Coplanar PCBs: Occurrence, Source, Persistency and Toxic Implications to Wildlife and Humans", Environmental Pollution, vol. 47, (1987) pp. 147-163.
Searle et al., "Building a Metal-Responsive Promoter with Synthetic Regulatory Elements", Molecular and Cellular Biology, vol. 5, No. 6, (1985) pp. 1480-1489.
Pons et al., "A New Cellular Model of Response to Estrogens: A Bioluminescent Test to Characterize (Anti)Estrogen Molecules", BioTechniques, vol. 9, No. 4, (1990) pp. 450-459.
Motojima, "Peroxisome Proliferator-Activated Receptor (PPAR): Structure, Mechanism of Activation and Diverse Functions", Cell Structure and Function, vol. 18, (1993) pp. 267-275.
Lee et al., "Functional Analysis of the Steroid Hormone Control Region of Mouse Mammary Tumor Virus", Nucleic Acids Research, vol. 12, No. 10, (1984) pp. 4191-4206.
Nelson et al., "P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers and Nomenclature", Pharmacogenetics, vol. 6, (1996) pp. 1-42.
Chen et al., "Subunit Composition of the Heteromeric Cytosolic Aryl Hydrocarbon Receptor Complex", The Journal of Biological Chemistry, vol. 269, No. 44, (1994) pp. 27554-27558.
Hord et al., "Physicochemical and Immunocytochemical Analysis of the Aryl Hydrocarbon Receptor Nuclear Translocator: Characterization of Two Monoclonal Antibodies to the Aryl Hydrocarbon Receptor Nuclear Translocator", Molecular Pharmacology, vol. 46, (1994) pp. 618-626.
Hahn et al., "Cytochrome P4501A Induction and Inhibition by 3,3', 4, 4'-Tetrachlorobiphenyl in an Ah Receptor-containing Fish Hepatoma Cell Line (PLHC-1)", Aquatic Toxicology, vol. 26, (1993) pp. 185-208.
Probst et al., "Role of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein in Aryl Hydrocarbon (Dioxin) Receptor Action", Molecular Pharmacology, vol. 44, (1993) pp. 511-518.
Sawyer et al., "PCB Isomers and Congeners: Induction of Aryl Hydrocarbon Hydroxylase and Ethoxyresorufin O-Deethylase Enzyme Activities in Rat Hepatoma Cells", Toxicology Letters, vol. 13, (1982) pp. 87-93.
Denison et al., "The DNA Recognition Site for the Dioxin-Ah Receptor Complex", The Journal of Biological Chemistry, vol. 263, No. 33, (Nov., 1988) pp. 17221-17224.
Aarts et al., "Species-Specific Antagonism of Ah Receptor Action by 2,2'5,5'-Tetrachloro-and 2,2',3,3',4,4'-Hexachlorobiphenyl", European Journal of Pharmacology, Environmental and Toxicology Section 293, (1995) pp. 463-474.
Alam et al., "Reporter Genes: Application to the Study of Mammalian Gene Transcription", Analytical Biochemistry, vol. 188, (1990) pp. 245-254.
Kennedy et al., "Ethoxyresorufin-O-deethylase and Porphyrin Analysis in Chicken Embryo Hepatocyte Cultures with a Fluorescence Multiwell Plate Reader", Analytical Biochemistry, vol. 211, (1993) pp. 102-112.
Garrison et al., "Species-Specific Recombinant Cell Lines as Bioassay Systems for the Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals", Fundamental and Applied Toxicology, vol. 30, No. 2, (Apr., 1996) pp. 194-203.
El-Fouly et al., "Production of a Novel Recombinant Cell Line for Use as a Bioassay System for Detection of 2,3 7,8-Tetrachlorodibenzo-p-dioxin-like Chemicals", Environmental Toxicoloy, vol. 13, No. 10, (1994) pp. 1581-1588.
Postlind et al., "Response of Human CYP1-Luciferase Plasmids to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Polycyclic Aromatic Hydrocarbons", Toxicology and Applied Pharmacology, vol. 118, (1993) pp. 255-262.
Anderson et al., "A Biomarker, P450 RGS, for Assessing the Induction of Environmental Samples", Environmental Toxicology and Chemistry, vol. 14, No. 7, (1995) pp. 1159-1169.
Albro et al., "Methods for the Quantitative Determination of Multiple, Specific Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Isomers in Human Adipose Tissue in the Parts-per-Trillion Range. An Interlaboratory Study", Anal. Chem., vol. 57, No. 13, (1985) pp. 2717-2725.
Okino et al., "2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces the Nuclear Translocation of Two XRE Binding Proteins in Mice", Pharmacogenetics, vol. 3, (1993) pp. 101-109.
Phillips et al., "Chlorinated Hydrocarbon Levels in Human Serum: Effects of Fasting and Feeding", Arch. Environ. Contam. Toxicol., vol. 18, (1989) pp. 495-500.
Yao et al., "DNA Sequence Determinants for Binding of Transformed Ah Receptor to a Dioxin-Responsive Enhancer", Biochemistry, vol. 31, No. 21, (1992) pp. 5060-5067.
Denison et al., "Inducible, Receptor-Dependent Protein-DNA Interactions at a Dioxin-Responsive Transcriptional Enhancer", Proc. Natl. Acad. Sci. USA, vol. 85, (1988) pp. 2528-2532.
Denison et al., "Xenobiotic-Inducible Transcription of Cytochrome P450 Genes", The Journal of Biological Chemistry, vol. 270, No. 31, (1995) pp. 18175-18178.
Helferich et al., "Ultraviolet Photoproducts of Tryptophan Can Act as Dioxin Agonists", Molecular Pharmacology, vol. 40, (1991) pp 674-678.
Richter et al., "Development of an in vitro Rainbow Trout Cell Bioassay for AhR-mediated Toxins", Organohalogen Compounds, vol. 21, (1994) pp. 213-216.
Ahlborg et al., "Toxic Equivalency Factors for Dioxin-line PCBs", Chemosphere, vol. 28, No. 6, (1994) pp. 1049-1063.
Safe, "Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-p-dioxins and Dibenzofurans", Ann. Rev. Pharmacol. Toxicol., vol. 26, (1986) pp. 371-399.
Casterline et al., "Screening of Fresh Water Fish Extracts for Enzyme-Inducing Substances by an Aryl Hydrocarbon Hydroxylase Induction Bioassay Technique", J. Assoc. Off. Anal. Chem., vol. 66, No. 5, (1983) pp. 1136-1139.
Fujisawa-Sehara et al., "Characterization of Xenobiotic Responsive Elements Upstream from Drug-Metabolizing Cytochrome P-450c Gene: A Similarity to Glucocorticoid Regulatory Elements", Nucleic Acids Research, vol. 15, No. 10, (1987) pp. 4179-4191.
Rappe et al., "Chemical Properties and Analytical Methods", Chp. 2 ofHalogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins, and Related Products, published by Elsevier/North-Holland Biomedical Press, (1980) pp. 41-59.
Whitlock, "The Regulation of Cytochrome P-450 Gene Expression", Ann. Rev. Pharmacol. Toxicol., vol. 26, (1986) pp. 333-365.
Thompson et al., "Modulation of Firefly Luciferase Stability and Impact on Studies of Gene Regulation", Gene, vol. 103, (1991) pp. 171-177.
Lusska et al., "Protein-DNA Interactions at a Dioxin-responsive Enhancer", The Journa
Brouwer Abraham
Clark George C.
Denison Michael S.
Brusca John S.
Elliott George C.
LandOfFree
Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1423439