Bioartificial pancreas

Details Bioartificial pancreas Bioartificial pancreas

1996-09-03

1999-01-05

Brittingham, Debra S.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

604 4, 604175, 424424, A61F 202, A61F 200

Patent

active

058556168

ABSTRACT:
An implantable bioartificial pancreas device having an islet chamber containing glucose responsive and insulin-secreting islets of Langerhans or similar hormone secreting cells, one or more vascularizing chambers open to surrounding tissue, a semi-permeable membrane between the islet and vascularizing chambers that allows passage of small molecules including insulin, oxygen and glucose and does not allow passage of agents of the immune system such as white cells and antibodies, the vascularizing chambers containing a growth factor soaked fibrous or foam matrix having a porosity of about 40 to 95%, the matrix providing small capillary growth and preventing the blood from clotting in the lower chamber.

REFERENCES:
patent: 5002661 (1991-03-01), Chick et al.
patent: 5100392 (1992-03-01), Orth et al.
patent: 5116493 (1992-05-01), Chick et al.
patent: 5116494 (1992-05-01), Chick et al.
patent: 5387237 (1995-02-01), Fournier et al.

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