Bioartificial liver system

Details Bioartificial liver system Bioartificial liver system

2007-01-09

2007-01-09

Naff, David M. (Department: 1651)

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

C424S093700, C435S325000, C435S370000

Reexamination Certificate

active

10164817

ABSTRACT:
A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.

REFERENCES:
patent: 4336329 (1982-06-01), Hesse et al.
patent: 4647539 (1987-03-01), Bach
patent: 4804628 (1989-02-01), Cracauer et al.
patent: 5202254 (1993-04-01), Amiot et al.
patent: 5270192 (1993-12-01), Li et al.
patent: 5270207 (1993-12-01), Matsumura et al.
patent: 5328614 (1994-07-01), Matsumura
patent: 5595909 (1997-01-01), Hu et al.
patent: 5605835 (1997-02-01), Hu et al.
patent: 5624839 (1997-04-01), Yada et al.
patent: 5658797 (1997-08-01), Bader
patent: 5981211 (1999-11-01), Hu et al.
patent: 6048727 (2000-04-01), Kopf
patent: 6096544 (2000-08-01), Bramble et al.
patent: 6190913 (2001-02-01), Singh
patent: 6218182 (2001-04-01), Naughton et al.
patent: 6228607 (2001-05-01), Kersten et al.
patent: 6582955 (2003-06-01), Martinez et al.
patent: 6602711 (2003-08-01), Thomson et al.
patent: 1 063 289 (2000-12-01), None
patent: WO 86/02379 (1986-04-01), None
patent: WO 92/07615 (1992-05-01), None
patent: WO 96/09876 (1996-04-01), None
patent: WO 99/32171 (1999-07-01), None
patent: WO 00/78920 (2000-12-01), None
patent: WO 00/78932 (2000-12-01), None
Asano et al., “Ultrastructure of Multicellular Spheroids Formed in the Primary Culture of Adult Rat Hepatocytes,”J. Clin. Electron Microscopy, 1989, 22(2):243-252.
Busse and Gerlach, “Bioreactors for Hybrid Liver Support: Historical Aspects and Novel Designs,”Ann. N.Y. Acad. Sci., 1999, 875:326-339.
Carrillo et al., “Multiaggregate Hepatocyte (HP) Spheroids in the Hepato-Cellular Transplant: Structural, Functional and Metabolic Characterization,”Transplantation Proceedings, 2001, 33:660-661.
Koide et al., “Continued High Albumin Production by Multicellular Spheroids of Adult Rat Hepatocytes Formed in the Presence of Liver-Derived Proteoglycans,”Biochem. Biophys. Res. Comm.1989, 161:385-391.
Koide et al., “Formation of Multicellular Spheroids Composed of Adult Rat Hepatocytes in Dishes with Positively Charged Surfaces and under Other Nonadherent Environments,”Exp. Cell Res., 1990, 186:227-235.
Lazar et al., “Formation of Porcine Hepatocyte Spheroids for Use in a Bioartificial Liver,”Cell Transplantation, 1995, 4:259-268.
Lazar et al., “Extended Liver-Specific Functions of Porcine Hepatocyte Spheroids Entrapped in Collagen Gel,”In Vivo Cell Dev. Biol., 1995, 31:340-346.
Matsumura et al., “Hybrid bioartificial liver in hepatic failure: Preliminary clinical report,”Surgery, 1987, 101:99-103.
Mueller-Klieser, “Three-dimensional cell cultures: from molecular mechanisms to clinical applications,”Am. J. Physiol., 1997, 273(Cell Physiol. 42):C1109-C1123.
Nishikawa et al., “Comparison of Assay Methods for Benzodiazepines in Urine,”Am. J. Clin. Pathol., 1997, 107(3):345-352.
Ota et al., “Xenotransplantation of Spheroidal Aggregate-Cultured Hepatocytes,”Trans. Proc., 1997, 29:912-913.
Saito et al., “Transplantation of Spheroidal Aggregate Cultured Hepatocytes into the Rat Spleen,”Trans. Proc., 1989, 21:2374-2377.
Sakaguchi et al., “Promotion of Spheroid Asembly of Adult Rat Hepatocytes by Some Factor(s) Present in the Initial 6-Hour Conditioned Medium of the Primary Culture,”Pathobiology, 1991, 59:351-356.
Sakai et al., “A New Bioartificial Liver Using Porcine Hepatocyte Spheroids in High-Cell-Density Suspension Perfusion Culture: In Vitro Performance in Synthesized Culture Medium and in 100% Human Plasma,”Cell Trans., 1999, 8:531-541.
Shinji et al. “Glycosaminoglycans Partially Substitute for Proteoglycans in Spheroid Formation of Adult Rat Hepatocytes in Primary Culture,”Cell Structure and Function, 1988, 13:179-188.
Sielaff et al., “A Technique for Porcine Hepatocyte Harvest and Description of Differentiated Metabolic Functions in Static Culture,”Transplantation, 1995, 59(10):1459-1463.
Strain and Neuberger, “A Bioartificial Liver—State of the Art,”Science, 2002, 295:1005-1009.
Wu et al., “Entrapment of Hepatocyte Spheroids in a Hollow Fiber Bioreactor as a Potential Bioartificial Liver,”Tissue Engineering, 1995, 1:29-40.
Yagi et al., “Caspase Inhibition Reduces Apoptotic Death of Cryopreserved Porcine Hepatocytes,”Hepatology, 2001, 33:1432-1440.
Yin et al., “Derivation, Characterization, and Phenotypic Variation of Hepatic Progenitor Cell Lines Isolated From Adult Rats,”Hepatology, 2002, 35:315-324.
Mashberg, T., “A Life-Saving Liver Machine,” Technology Review, Mar. 28, 2006, 3 pages, retrieved from http://www.technologyreview.com/read—article.aspx?ch=biotech&sc=&id=16637&pg=1.

Affiliated with

Also associated with

Rating

Bioartificial liver system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioartificial liver system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioartificial liver system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3812914