Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2004-11-15
2009-06-16
Gitomer, Ralph (Department: 1657)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S427000, C424S422000, C424S093700, C435S371000
Reexamination Certificate
active
07547447
ABSTRACT:
The present invention provides a bioartificial lacrimal gland which contains at least one unit that includes (a) a permeable housing having an interior and an exterior; (b) an outlet connecting the housing interior to the housing exterior; and (c) a population of lacrimal epithelial cells within the housing interior.
REFERENCES:
patent: 6331313 (2001-12-01), Wong et al.
patent: 6743626 (2004-06-01), Baum et al.
patent: 2003/0031696 (2003-02-01), Baum et al.
patent: WO 00/50049 (2000-08-01), None
Casbon et al., “Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro,”Adv. Exp. Med. Biol. 506(Pt A):231-235 (2002).
Hann et al., “Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland,”Invest. Ophthalmol Vis. Sci. 32(9):2610-2621 (1991).
Hann et al., “Morphology and function of lacrimal gland acinar cells in primary culture,”Invest Ophthalmol. Vis. Sci. 30(1):145-158 (1989).
Huang et al., “Analysis of cytomegalovirus infection and replication in acinar epithelial cells of the rat lacrimal gland,”Invest. Ophthalmol. Vis. Sci. 37(6):1174-1186 (1996).
Stevenson et al., “A new model system for studying lacrimal physiology using cultured lacrimal gland acinar cells on Matrigel® rafts,”Adv. Exp. Med. Biol. 506(Pt A):159-163 (2002).
Vanaken et al., “Primary rat lacrimal cells undergo acinar-like morphogenesis on reconstituted basement membrane and express secretory component under androgen stimulation,”Exp. Cell. Res. 238(2):377-388 (1998).
Yoshino, K., “Establishment of a human lacrimal gland epithelial culture system with in vivo mimicry and its substrate modulation,”Cornea19(Suppl. 1):S26-S36 (2000).
Yoshino, K., “Substrate modulation of morphology, growth, and tear protein production by cultured human lacrimal gland epithelial cells,”Exp. Cell. Res.220(1):138-151 (1995).
Aframian et al., “Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland,”Tissue Eng. 8(5):871-878 (2002).
Aframian et al., “The growth and morphological behavior of salivary epithelial cells on matrix protein coated biodegradable substrata,” Tissue Eng. 6:209-216 (2000).
Agre et al., “The aquaporins, blueprints for cellular plumbing systems,”J. Biol. Chem. 273(24):14659-14662 (1998).
Baum, “Principles of saliva secretion,”Ann. NY Acad. Sci. 694:17-23 (1993).
Baum, “Prospects for Re-engineering Salivary Glands,”Adv. Dent. Res. 14:84-88 (2000).
Cao et al., “Transplantation of chondrocytes utilizing a polymer cell construct to produce tissue-engineered cartilage in the shape of a human ear,”Plast. Reconstr. Surg. 100(2):297-304 (1997).
Davis and Vacanti, “Toward development of an implantable tissue engineered liver,”Biomaterials17 (3):365-372 (1996).
Guo et al., “Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations,”Exp. Eye. Res. 71(1):11-22 (2000).
Johnson and Murphy, “Changes in the tear film and ocular surface from dry eye syndrome,”Prog. Retin. Eye Res. 23(4):449-474 (2004).
Kim and Mooney, “Development of biocompatible synthetic extracellular matrices for tissue engineering,”Trends Biotechnol. 16(5):224-230 (1998).
Kim et al., “Engineered smooth muscle tissues: regulating cell phenotype with the scaffold,”Exp. Cell Res.: 251(2):318-328 (1999).
Kleinman et al., “Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma,”Biochem. 21(24):6188-6193 (1982).
Langer and Vacanti, “Tissue engineering,”Science260(5110):920-926 (1993).
Meneray et al. “Morphology and physiologic responsiveness of cultured rabbit lacrimal acini,”Invest. Ophthalmol. Vis. Sci. 35(12):4144-4158 (1994).
Mostov et al., “Membrane traffic in polarized epithelial cells,”Curr. Opin. Cell Biol. 12(4):483-490 (2000).
Nerem and Sambanis, “Tissue engineering: From biology to biological substitutes,”Tissue Engineering1(1):3-13 (1995).
Nguyen et al., “Characterization of immortalized rabbit lacrimal gland epithelial cells,”In Vitro Cell Dev. Biol. Anim. 35(4):198-204 (1999).
Oberpenning et al., “De novo reconstitution of functional mammalian urinay bladder by tissue engineering,”Nat. Biotechnol. 17:149-155 (1999).
Pastan and Bailey, “Dialysis therapy,”New Engl. J. Med. 338(20):1428-1437 (1998).
Saarloos et al., “Intermediate filament, laminin and integrin expression in lacrimal gland acinar cells: Comparison of an immortalized cell line to primary cells, and their response to retinoic acid,”Curr. Eye Res. 19(5):439-449 (1999).
Schaumberg et al., “Epidemiology of dry eye syndrome,”Adv. Exp. Med. Biol. 506 (Part B):989-998 (2002).
Schechter et al., “Growth of purified lacrimal acinar cells in matrigel raft cultures,”Exp. Eye Res. 74:349-360 (2002).
Schonthal et al., “Proliferation of lacrimal gland acinar cells in primary culture. Stimulation by extracellular matrix, EGF, and DHT,”Exp Eye Res. 70(5):639-649 (2000).
Sheridan et al., “Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth delivery,”J. Control. Rel. 64:91-102 (2000).
Smith, Slide presentation at the American Academy of Ophthalmology 2003 Annual Meeting, Nov. 17, 2003.
Tsubota, “Understanding dry eye syndrome. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3 Basic Science and Clinical Relevance,”Adv. Exp. Med. Biol. 506 (Part A):3-16 (2002).
Jacob Jean
Mircheff Austin K.
Smith Ronald E.
Trousdale Mel
Yiu Samuel C.
Doheny Eye Institute
Gitomer Ralph
Gough Tiffany M
McDermott Will & Emery LLP
The Board of Supervisors of Louisiana State University and Agric
LandOfFree
Bioartificial lacrimal gland does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioartificial lacrimal gland, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioartificial lacrimal gland will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4143875