Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1995-12-07
1998-11-10
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
5147723, 623 11, 435182, A61F 202, A61K 4730, C12N 1104
Patent
active
058340050
ABSTRACT:
A device for the effective release of cellular moieties, including hormones, wherein a matrix containing a hormone producing cellular moiety is encapsulated with a non-immunogenic polymeric material of poly-para-xylylene or other aromatic based polymer moiety having a membrane portion with a porosity blocking passage therethrough of immunogenic agents and permitting passage therethrough of effective nutrients for said cellular moiety and the hormone produced thereby, an improved matrix for the storage, manufacture, functional testing, and viral infection testing of cellular moieties wherein a collagen based hydrogel is processed to present a liquid phase at host temperature and functions as a substrate for cellular attachment with additives effective for limiting thermal and pressure trauma, and an improved method for the harvesting tissue from organs.
REFERENCES:
patent: 4696286 (1987-09-01), Cochrum
patent: 4797213 (1989-01-01), Parisius et al.
patent: 4868121 (1989-09-01), Scharp et al.
patent: 5079160 (1992-01-01), Lacy et al.
patent: 5322790 (1994-06-01), Scharp et al.
P. Metrakos et al., Collagan Gel Metrix Promotes Islet Cell Proliferation, Trnasplantation Proceeds 26(6):3349-3350 (1994).
Azpuru Carlos
Encelle, Inc.
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