Bioadhesive polyethylene glycol ointment for medicaments

Details Bioadhesive polyethylene glycol ointment for medicaments Bioadhesive polyethylene glycol ointment for medicaments

1992-04-01

1998-02-03

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514928, 514969, 514944, A61K 906, A61K 4732, A61K 4734, A61K 910

Patent

active

057141657

ABSTRACT:
A therapeutic composition having wet adherent properties and particularly useful for delivery of medicaments to mucosal surfaces comprises a therapeutically effective amount of a medicament dispersed in a base material comprising from about 3 to 15% by weight of a water soluble salt of a copolymer of methyl vinyl ether and maleic acid or anhydride and from about 85 to 97% by weight of polyethylene glycol. Formulations of the base material with triamcinolone acetonide and lidocaine are particularly efficacious in the treatment of recurrent aphthous ulcers.

REFERENCES:
patent: Re33093 (1989-10-01), Schiraldi et al.
patent: 4307075 (1981-12-01), Martin
patent: 4627977 (1986-12-01), Gaffar et al.
patent: 4764378 (1988-08-01), Keith et al.
patent: 4765983 (1988-08-01), Takayanagi et al.
patent: 4883660 (1989-11-01), Blackman et al.
patent: 4910247 (1990-03-01), Haldar et al.
patent: 4948580 (1990-08-01), Browning
"Topical Mucosal Adhesive Dosage Forms", T. Nagi, Medicinal Research Reviews, vol. 6, No. 2,227-242 (1986).

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