Bioadhesive extruded film for intra-oral drug delivery and proce

Details Bioadhesive extruded film for intra-oral drug delivery and proce Bioadhesive extruded film for intra-oral drug delivery and proce

1986-06-16

1987-12-15

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424449, 424435, A01N 5910, A61K 3316

Patent

active

047132434

ABSTRACT:
A bioadhesive extruded single or multi-layered thin film, especially useful in intra-oral controlled-releasing delivery, having a water soluble or swellable polymer matrix bioadhesive layer which can adhere to a wet mucous surface and which bioadhesive layer consists essentially of 40-95% by weight of a hydroxypropyl cellulose, 5-60% of a homopolymer of ethylene oxide, 0-10% of a water-insoluble polymer such as ethyl cellulose, propyl cellulose, polyethylene and polypropylene, and 2-10% of a plasticizer, said film having incorporated therein a medicament, e.g., anesthetics, analgesics, anticaries agents, anti-inflammatories, antihistamines, antibiotics, antibacterials, fungistats, etc.

REFERENCES:
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4421738 (1983-12-01), Yamigawa et al.
patent: 4517173 (1985-05-01), Kizawa et al.

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