Bioadhesive emulsion preparations for enhanced drug delivery

Details Bioadhesive emulsion preparations for enhanced drug delivery Bioadhesive emulsion preparations for enhanced drug delivery

1993-08-13

1998-04-28

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424435, 424436, 424450, 514937, 514938, A61K 9107

Patent

active

057441553

ABSTRACT:
The invention relates to an oil-in-water emulsion and related method for administration of a drug to a mucosal surface. The emulsion has an aqueous continuous phase and a plurality of submicron particles having an average particle diameter of from 10 nm to 600 nm, with the particles having a hydrophobic core of a fat or oil which is surrounded by a surfactant layer. The emulsion further includes a drug and a mucoadhesive polymer which is a polymer or copolymer of acrylic acid or methacrylic acid, a poly(methyl vinyl ether/maleic anhydride) copolymer, pectin, alginic acid, hyaluronic acid, chitosan, gum tragacanth, karaya gum or carboxymethylcellulose. The hydrophobic core has less than 1% (w/w) protein, relative to the weight of the hydrophobic core, and the emulsion contains less than 5% (w/w) surfactant, relative to the weight of the hydrophobic core.

REFERENCES:
patent: 4548922 (1985-10-01), Carey et al.
patent: 5055303 (1991-10-01), Riley, Jr.
patent: 5120710 (1992-06-01), Liedtke
patent: 5188837 (1993-02-01), Domb
Longer, M.A. and J.R. Robinson. (1986). Pharmacy International, May Issue, pp. 114-117.
Nagai, T. and Y. Machida. (1985). Pharmacy International, Aug. Issue, pp. 196-200.
J. Pharm. Parmacol (1992), 44 (Suppl. 1): 186-190.
Meth Find Exp Clin Parmacol (1991), 13(3): 205-220.

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