Bioadaptable porous crystalline glass containing an immobilized

Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an...

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424 9463, C12N 1114, A61K 3754

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active

052906922

ABSTRACT:
A fibrinolytic enzyme such as urokinase, tissue plasminogen activator or streptokinase is covalently bounded to a bioadaptable porous crystalline glass to produce a thrombolytic material. Production of the glass involves combining 40-50 mol% calcium oxide, 20-30 mol% titanium dioxide and 25-35 mol% diphosphorous pentoxide to form a mixture, and combining the mixture with 0.5-4.0 mol% disodium oxide. A bioreactor for converting plasminogen in blood into plasmin can be prepared by packing the material in a column. When finely comminuted, the material can be administered into the blood of a patient for removing blood clots.

REFERENCES:
patent: 4764466 (1988-08-01), Suyama et al.
patent: 5178901 (1993-01-01), Toriyama et al.
Biochim. Biophys. Acta. vol. 24 (1957), pp. 278-282, Jorgen Ploug, et al. Urokinase An Activator Of Plasminogen From Human Urine.
Agric. Biol. Chem. 55(5), pp. 1225-1232 (1991), Yasuhara Itagaki, et al. Purification & Characterization of Tissue Plasminogen Activator Secreted By Human Embryonic Lung Diploid Fibroblasts, IMR-90 Cells.
Biotechnology and Bioengineering, vol XXI pp. 461-476 (1979) John Wiley & Son's, Inc., Y. K. Cho, et al. Immobilization Of Enzymes On Activated Carbon: Selection Preparation Of The Carbon Support.
Science, vol. 166, pp. 615 to 617 (1969), Howard H. Weetall, Trypsin And Papain Covalently Coupled To Porous Glass: Preparation And Characterization.

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