Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1997-01-21
1998-05-26
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435118, 4352535, 435261, 435886, 548427, 548428, 548430, 548432, C12P 1700, C12P 1716, C12P 120, C07D20956
Patent
active
057563209
ABSTRACT:
Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive substances K93-0711 I-1 and I-2 accumulate in the medium. These bioactive substances K93-0711 I-1 and I-2 are then isolated therefrom. The substances are effective for treatment of IL-6-involving diseases such as cancer cachexia, multiple myeloma and rheumatoid arthritis.
REFERENCES:
A. Kawashima, et al., "Preparation of Fluorinated Antibiotics Followed by .sup.10 F NMR Spectroscopy", The Journal of Antibiotics, vol. XXXIX No. 10, Oct. 1986, pp. 1495-1497.
I. Saito, et al., "Peroxidic Intermediates in Indole-Singlet Oxygen Reactions; Mechanism of the C.sub.2- C.sub.3 Ring Cleavage of Tryptophol", Feb. 1978, pp. 531-534.
Y. Nihel, et al., "Epocarbazolins A and B, Novel 5-Lipoxy-genase Inhibitors", The Journal of Antibiotics, vol. 46, No. 1, 1992, pp. 25-33.
J. R. Anderson et al., "Punctatins B & C(Antibiotics M95154 and M95155): Further Sesquiterpene Alcohols from the Fungus Poronia punctata", J. Chem. So., Chem., Commun., 1984, pp. 917-919.
T. Yamashita et al., "Isolation of a new Indole Alkaloid, Pendolmycin, from Nocardiopsis", Journal of Natural Products, vol., 51, No. 6, Nov-Dec. 1988, pp. 1184-1187.
J. H. Rigby et al., "Convergent Total Synthesis of (.+-.) Tenellin", J. Org. Chem., vol. 54, 1989, pp. 5852-5853.
M. Norte et al., "Three New Bromo Ethers from the Red Alga Laurencia Obtusa", Tetrahedron, vol. 45, No. 18, 1989, pp. 5987-5994.
R. E. Schwartz et al., "Pramanicin, a Novel Antimicrobial Agent from a Fungal Fermentation", Tetrahedron, vol. 50, No. 6, 1994, pp. 1675-1686.
V. R. Hegde et al., "Isolation and Structure of two novel Muscarinic Receptor Antagonists", Journal of Natural Products, vol. 58, No. 6, Jun. 1995, pp. 843-847.
M. Benn et al., "Hetisine 13-0-Acetate, A New Diterpenoid Alkaloid from Delphinium Nuttallianum Pritz", Heterocycles, vol. 24, No. 6, 1986, pp. 1605-1607.
D. W. Hughes et al., "C magnetic resonance spectra of some isoquinoline alkaloids and related model compounds", Can. J. Chem., vol. 54, 1976, pp. 2252-2260.
Sun Fang et al., "A new C.sub.20 -Diterpene Alkaloid, Spirasing III and the Interconversion of Oxazolidine Ring", Hetero-cycles, vol. 26, No. 1, 1987, pp. 19-23.
V. D. Gorbunov, "Structure of spireine", Chemical Abstracts, vol. 72, 1970, p. 67159.
Yang-Chang Wu et al., "Thalicsessine, A. new C.sub.20 -Diterpenoid Alkaloid from Thalictrum Sessile Hayata", Heterocycles, vol. 26, No. 4, 1987, pp. 943-943.
M. Leboeuf et A. Cave, "Alcaloides Des Ecorces De L'Uvariopsis Guineensis", Phytochemistry, 1972, vol. II, pp. 2833-2840.
Masahiko Hayashi et al., The Journal of Antibiotics., vol. 49, No. 11, pp. 1091-1095, 1996.
Hayashi Masahiko
Komiyama Kanki
Omura Satoshi
Takamatsu Satoshi
Achutamurthy Ponnathapura
Ponnaluri Padmashri
The Kitasato Institute
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