Bioactive peptides and peptide derivatives of parathyroid...

Details Bioactive peptides and peptide derivatives of parathyroid... Bioactive peptides and peptide derivatives of parathyroid...

2011-07-26

2011-07-26

Spector, Lorraine (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C530S328000, C514S001100, C514S005300, C514S016700, C514S021500, C514S021600, C424S001110

Reexamination Certificate

active

07985835

ABSTRACT:
Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.

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