Bioactive medical films

Details Bioactive medical films Bioactive medical films

2007-11-20

2007-11-20

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

C424S445000, C514S008100, C514S056000

Reexamination Certificate

active

10684022

ABSTRACT:
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a hydrophobic prosthetic moiety, with one or more bioactive molecules directly complexed to the polyanion. The polyanion may be heparin or a heparin-activity molecule. The prosthetic group may include a hydrophobic silyl-containing moiety. Bioactive molecules include adhesive molecules, growth factor molecules, and therapeutic molecules, including antibiotics.

REFERENCES:
patent: 5147339 (1992-09-01), Sundstrom
patent: 5667810 (1997-09-01), Levin
patent: 5807295 (1998-09-01), Hutcheon et al.
patent: 5876730 (1999-03-01), Brigstock et al.
patent: 5902798 (1999-05-01), Gouda et al.
patent: 5906828 (1999-05-01), Cima et al.
patent: 5955588 (1999-09-01), Tsang et al.
patent: 6245753 (2001-06-01), Byun et al.
patent: 6342591 (2002-01-01), Zamora et al.
patent: 6486140 (2002-11-01), Hansson et al.
patent: 2001/0038862 (2001-11-01), Luo et al.
patent: 2001/0053839 (2001-12-01), Noishiki et al.
patent: 2001/0056079 (2001-12-01), Hansson et al.
patent: 2002/0018813 (2002-02-01), Burns et al.
patent: 2002/0048563 (2002-04-01), Baetge et al.
patent: 2002/0064551 (2002-05-01), Edwards et al.
patent: 2002/0064559 (2003-05-01), Lee et al.
patent: WO 92/13553 (1992-08-01), None
patent: WO 02/10221 (2002-02-01), None
Ishihara M, Saito Y, Yura H, Ono K, Ishikawa K, Hattori H, Akaike T, Kurita D.J: Heparin-carrying polystyrene to mediate cellular attachment and growth via interaction with growth factors. Biomed Mater Res May; 50(2): 144-52 (2000).
Cox, M.D., David A., et al., “Effect of Local Delivery of Heparin and Methotrexate on Neointimal Proliferation in Stented Procine Coronary Arteries”,Coronary Artery Disease, Current Science, vol. 3, (1992),237-248.
Edelman, Elazer R., et al., “Basic Fibroblast Growth Factor Enhances the Coupling of Intimal Hyperplasia and Proliferation of Vasa Vasorum in Injured Rat Arteries”,J. Clin. Invest., vol. 89, (Feb. 1992),465-473.
Ksander, George A., et al., “Exogenous Transforming Growth Factor-Beta 2 Enhances Connective Tissue formation and Wound Strength in Guinea Pig Dermal Wounds Healing by Secondary Intent”,Ann. Surg., (Mar. 1990),288-294.
Sellke, Frank W., “Therapeutic Angiogenesis with Basic Fibroblast Growth Factor: Technique and Early Results”,Ann. Thorac Surg 1998:65:1540-4, (1988), 1540-1544.

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