Bioactive materials, methods of making bioactive materials...

Details Bioactive materials, methods of making bioactive materials... Bioactive materials, methods of making bioactive materials...

2002-10-25

2010-06-01

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C530S353000

Reexamination Certificate

active

07727542

ABSTRACT:
A bioactive material is made using fibroin solutions and suspensions that can be used alone or as a composite with particles such as core/shell particles. The material is designed to support the constructions, repair, regeneration or augmentation of bone and other tissues of the body. The solutions and suspensions can be loaded with core/shell-type particles comprising inorganic core materials that are coated with biodegradable polymers with an outer coating of a calcium phosphate precursor. The fibroin solutions, suspensions, and composites can be injected to fill cavities or to replace missing tissue. After injection, the materials can produce a scaffold capable of promoting tissue regeneration while degrading. The degradation of the particles, when present, can generate additional porosity within the scaffold and release other compounds in a controlled manner to enhance growth and activation of the cells necessary for tissue repair. The ability to inject the fibroin solutions, suspensions and composites can reduce the need for many types of surgical procedures that are used to replace or repair bone and other tissues.

REFERENCES:
patent: 4233211 (1980-11-01), Ohtomo et al.
patent: 4490984 (1985-01-01), Hongo et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4818291 (1989-04-01), Iwatsuki et al.
patent: 5480644 (1996-01-01), Freed
patent: 5490984 (1996-02-01), Freed
patent: 5599852 (1997-02-01), Scopelianos et al.
patent: 5728752 (1998-03-01), Scopelianos et al.
patent: 5824333 (1998-10-01), Scopelianos et al.
patent: 5863984 (1999-01-01), Doillon et al.
patent: 5939323 (1999-08-01), Valentini et al.
patent: 6140452 (2000-10-01), Felt et al.
patent: 6218357 (2001-04-01), Terauchi
patent: 0 513 803 (1992-11-01), None
patent: WO 01/25403 (2001-04-01), None
patent: WO 02/29141 (2002-04-01), None
Tsukada, M. et al.; “structural Changes of Silk Fibroin Membranes Induced by Immersion in Methanol Aqueous Solutions”; Journal of Polymer Science: Part B: Polymer Physics, vol. 32, (1994); pp. 961-968.
Kesenci, K., et al; “Poly(e-casprolactone-co-D, L-lactide) / silk fibroin composite materials: preparation and characterization”J. Biomater Sci Polym Ed 2001;12 (3): pp. 337-51.
Kurosaki, S., et al.; “Fibroin allergy”;J. Nippon Med Sch 1999: 66(1); pp. 41-44.
Motta, A., et al.; “Regenerated Silk Fibroin Films: Thermal and Cynamic Mechanical Analysis”;Macromol. Chem. Phys. 2002,203, pp. 1658-1665.
Motta, A. et al.; “Silk Derived Fibroin Membranes for Biomedical Use”;Third International Symposium on Frontiers in Biomedical Plymers Including Polymer Therapeutics—From Labroatory to Clinical PracitceAbstract, Shigha Japan, May 1999.
Santin, M., et al.; “In vitro evaluationof the inflammatory potential of the silk fibroin”; J. Biomed. Maker. Res 1999, 46(43): pp. 382-389.
Tsukada, M., et al.; “Structural Changes of Silk Fibroin Membranes Induced by Immersion in Methanol Aqueous Solutions”;Journal of Polymer Science: Part B: Polymer Physics,vol. 32, (1994); pp. 961-968.
Database WPI, Section Ch, Week 198123, Derwent Publications Ltd., London, GB; AN 1981-40786D XP002235614 & JP 56 040156 A (Kanebo Ltd), Apr. 16, 1981, Abstract.
Database WPI Section Ch, Week 200147, Derwent Publications Ltd., London,G B; AN 2001-433340 XP002235615 & CN 1 293 952 A (Univ Wuhan) May 9, 2001, Abstract.
Database WPI Section Ch, Week 199001 Derwent Publications Ltd., London, GB; AN 1990-004589 XP002235616 & JP 01 288269 A (TOA Nenryo Kogyo KK), Nov. 20, 1989, Abstract.
Yang G et al.: “Structure and microporous formation of cellulose/silk fibroin blend membranes—I Effect of coagulants” Journal of Membrane Science, Elsevier Science, Amsterdam, NL, vol. 177, No. 1-2, Aug. 30, 2000, pp. 153-161 XP004215319 ISSN: 0376-7388 ,Abstract.
Kweon H et al.: “Structural and thermal characteristics ofAntheraea pernyisilk fibroin/chitosan blend film” Polymer, Elsevier Science Publishers B.V., GB, vol. 42, No. 15, Jul. 2001, pp. 6651-6656, XP004235369 ISSN: 0032-3861, Abstract.
Database WPI Section Ch, Week 198947, Derwent Publications Ltd., London, GB; AN 1989-343221, XP002235613 & JP 01 254621 A (Terumo Corp), Oct. 11, 1989, Abstract.
Havawa, et al.;“New Oral Dosage form for Elderly Patients: Preparation and Characterization of Silk Fibroin Gel”; Chem. Pharm. Bull,vol. 43, No. 2, 1995; pp. 284-288 .
Database PAJ; JP 11 18544 A (Minoura Norihiko); May 11, 1989.
International Search Report; International Application No. UCT PCT/US 02/34252; International Filing Date Oct. 25, 2002; Date of Mailing Apr. 8, 2003.

Affiliated with

Also associated with

Rating

Bioactive materials, methods of making bioactive materials... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioactive materials, methods of making bioactive materials..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioactive materials, methods of making bioactive materials... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4201203