Compositions: ceramic – Ceramic compositions – Glass compositions – compositions containing glass other than...
Patent
1995-06-02
1997-07-15
Bell, Mark L.
Compositions: ceramic
Ceramic compositions
Glass compositions, compositions containing glass other than...
501 55, 501 63, 501 70, C03C 3087, C03C 3097
Patent
active
056483015
ABSTRACT:
Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO.sub.2, CaO, Na.sub.2 O and P.sub.2 O.sub.5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.
REFERENCES:
patent: 3922155 (1975-11-01), Broemer et al.
patent: 3981736 (1976-09-01), Broemer et al.
patent: 4171544 (1979-10-01), Hench et al.
patent: 4605415 (1986-08-01), Richez
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4620327 (1986-11-01), Caplan et al.
patent: 5204106 (1993-04-01), Schepers et al.
patent: 5429996 (1995-07-01), Kaneko
Cheung et al., "Growth of Osteoblasts on Porous Calcium Phosphate Ceramic: An in Vitro Model for Biocompatibility Study", Biomaterials 1989, 10, 63-67 No Month.
Cheung et al., "In Vitro Cartilage Formation of Porous Hydroxyapatite Ceramic Granules", In Vitro Cellular & Developmental Biology 1985, 21(6), 353-357 No Month.
Davies et al., "Early Extracellular Matrix Synthesis by Bone Cells", Bone-Biomaterials Workshop, editor J.E. Davies, University of Toronto Press, Dec. 1990.
Davies, J.E., ed., "The Bone-Material Interface" in the Preface, University of Toronto Press, 1991 No Month.
Ducheyne et al., "The Effects of Plasma-Sprayed Calcium Phosphate Ceramic Coatings on the Metal Ion Release from Porous Titanium and Cobalt-Chromium Alloys", J. of Biomedical Materials Res. 1988, 22, 1137-1163 No Month.
Ducheyne, P., "Bioglass Coatings and Bioglass Composites as Implant Materials", J. of Biomedical Materials Res. 1985, 19, 273-291 No Month.
Freshney et al., "Animal Cell Culture a Practical Approach", Freshney, R.I., ed., IRL Press, Oxford, 1986 No Month.
Greenlee et al., "Glass-Ceramic Bone Implants", J. Biomedical Materials Res. 1972, 6, 235-244 No Month.
Gregoire et al., "The Influence of Calcium Phosphate Biomaterials on Human Bone Cell Activities: An In Vitro Approach", J. Biomed. Mat. Res. 1990, 24, 165-177 No Month.
Gross, U. and Strunz, "The Interface of Various Glasses and Glass Ceramics with a Bony Implantation Bed", J. of Biomed. Materials Res. 1985, 19, 251-271 No Month.
Hench et al., "Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials", J. Biomed. Mat. Res. 1972, 2, 117-141 No Month.
Katsufumi et al., "The Influence of Calcium Phosphate Ceramics and Glass Ceramics on Cultured Cells and Their Surrounding Media", J. Biomed. Mat. Res. 1989, 23, 1049-1066 No Month.
Kim et al., "Early Stages of Calcium Phosphate Layer Formation in Bioglass", J. Non.-Cryst. Solids. 1989, 113, 195-202 No Month.
Koeneman et al., "Workshop on Characterization of Calcium Phosphate Materials", J. of Applied Biomaterials 1990, 1, 79-90 No Month.
Kokubo et al., "Solutions Able to Reproduce In Vivo Surface-Structure Changes in Bioactive Glass-Ceramic A-W.sup.3 ", J. Biomed. Mat. Res. 1990, 24, 721-734 No Month.
Kokubo, T. et al., "Ca, P-rich Layer Formed on High-strength Bioactive Glass-ceramic A-W", J. of Biomed. Mat. Res. 1990, 24, 331-343 No Month.
Lowenberg et al., "Mineralized Matrix Production by Osteoblasts on Solid Titanium in Vitro", Cells & Materials 1991, 1(2), 177-187 No Month.
Lowry et al., "The Quantitative Histochemistry of the Brain. II. Enzyme Measurements", J. Biol. Chem. 1954, 207, 19-37 No Month.
Maniatopoulos et al., "Bone Formation in Vitro by Stromal Cells Obtained from Bone Marrow of Young Adult Rats", Cell Tissue Res. 1988, 254, 317-330 No Month.
Matsuda et al., "The In Vitro Response of Osteoblasts to Bioactive Glass", Biomaterials 1987, 8, 275-284 No Month.
Ohgushi et al., "Osteogenic Capacity of Rat and Human Marrow Cells in Porous Ceramics", Acta Orthop. Scand. 1990, 61(5), 431-434 No Month.
Ohgushi et al., "Heterotopic Osteogenesis in Porous Ceramics Induced by Marrow Cells", J. Ortho. Res. 1989, 7, 568-578 No Month.
Ohtsuki, C. et al., "Apatite Formation on the Surface of Ceravital-type Glass-ceramic in the Body", J. of Biomedical Materials Res. 1991, 25, 1363-1370 No Month.
Orly et al., "Effect of Synthetic Calcium Phosphate on the .sup.3 -Thymidine Incorporation and Alkaline Phosphatase Activity of Human Fibroblasts in Culture", J. Biomed. Mat. Res. 1989, 23, 1433-1440 No Month.
Puleo et al., "Osteoblast Responses to Orthopaedic Implant Materials in Vitro", J. Biomed. Mat. Res. 1991, 25, 711-723 No Month.
Schepers et al., "Bioactive Glass Particles of Narrow Size Range: A New Material for the Repair of Bone Defects", Implant Dent. 1993, 2, 151-156 No Month.
Schepers et al., "Bioactive Glass Particulate Material as a Filler for Bone Lesions", J. Oral Rehabilitation 1991, 8, 435-452 No Month.
Uchida et al., "Growth of Bone Marrow Cells on Porous Ceramics in Vitro", J. Biomed. Mat. Res. 1987, 21, 1-10 No Month.
Vrouwenvelder et al., "Better Histology and Biochemistry for Osteoblasts Cultured on Titanium-Doped Bioactive Glass: Bioglass 45S5 Compared with Iron-, Titanium-, Fluorin- and Boron-Containing Bioactive Glasses", Biomaterials 1994, 15, 97-110 No Month.
Vrouwwenvelder et al., "Behaviour of Fetal Rat Osteoblasts Cultured IN Vitro on Bioactive Glass and Nonreaactive Glasses", Biomaterials 1992, 13(6), 382-392 No Month.
Vrouwenvelder et al., "Histological and Biochemical Evaluation of Osteoblasts, Cultured on Bioactive Glass, Hydroxylapatite, Titanium Alloy, and Stainless Steel", J. Biomed. Mat. Res. 1993, 27, 465-475 No Month.
Pernot et al. "Phosphate Glass-Ceramic for Bone Implants," in Ceramics in Surgery, edited by P. Vincenzini, Elsevier, Amsterdam 1983 pp. 177-186.
Ducheyne Paul
El-Ghannam Ahmed
Shapiro Irving
Bell Mark L.
Troilo Louis M.
Trustees of the University of Pennsylvania
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