Bioactive agents and compositions for materials comprising the b

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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424439, 424442, 426322, 426335, 426532, 425244, 530400, A23L 33463, A61K 3714, C07K 1522, C12N 138

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active

052964647

ABSTRACT:
Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.

REFERENCES:
patent: 5240909 (1993-08-01), Nitsche
"Iron-Binding Proteins in Milk and Resistance to Escherichia coli Infection in Infants" by J. J. Bullen et al, British Medical Journal, Jan. 8, 1972, pp. 69-75, 1972.
"Comparative Studies on the Chemical and Immunochemical Properties of Human Milk, Human Pancreatic Juice and Bovine Milk Lactoferrin", Chi-Sun Wang et al, Comp. Biochem. Physiol, vol. 78B, No. 3, pp. 575-580, 1984.
"Comparative Study of the Primary Structures of Sero-, Lacto- and Ovotrans-Ferrin Glycans from Different Species", by G. Spik et al, Biochimie 70 (1988), pp. 1459-1469.
"Isolation and Characterisation of Lactoferrin Separated from Human Whey by Adsorption Chromatography Using Cibacron Blue F3G-A Linked Affinity Adsorbent", Clinica Chimica Acta, 157 (1986) pp. 89-93, by W. R. Bezwoda et al.
"Milk Proteins, Chemistry and Molecular Biology", vol. II, 1971, Academic Press, Edited by Hugh A. McKenzie, Chapter 16 on Minor Milk Proteins and Enzymes, pp. 367-375.
"Zinc and Copper Binding Proteins in Human Milk", The American Journal of Clinical Nutrition 36: Dec. 1982, by Bo Lonnerdal et al, pp. 1170-1176.
"Lactofferin in Milk from Different Species", Comp. Biochem. Physiol., 1971, vol. 39B, pp. 119-129, by P. L. Masson et al., Pergamon Press/Great Britain.
Welsh et al., The Journal of Pediatrics, vol. 94 (1979), pp. 1-9.
Nonnecke et al., Journal of Dairy Science, vol. 67 (1984), pp. 606-613.
Stephens et al., Immunology, vol. 41 (1980), pp. 597-603.
Blakeborough et al., Zinc Binding in Cow's Milk and Human Milk, vol. 209, Biochem. J (1983), pp. 505-512, Great Britain.
Broxmeyer et al., Specificity and Modulation of the Action of Lactoferrin, a Negative Feedback Regulator of Myelopoiesis, Blood, vol. 55, No. 2 (1980), pp. 324-333.
Davidson et al., Fe-Saturation and Proteolysis of Human Lactoferrin: Effect on Brush-Border Receptor-Mediated Uptake of Fe and Mn, Am. J. Physiol., vol. 257 (1989), G930-4.
Lonnerdal et al., Manganese Binding Proteins in Human and Cow's Milk The American Journal of Clinical Nutrition, vol. 41 (1985), pp. 550-559, USA.

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