Bioactive acetogenins and derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549323, C07D30740, C07D30758

Patent

active

055368484

ABSTRACT:
Novel acetogenins isolated from Asimina triloba and Goniothalamus giganteus of the family Annonaceae and derivatives of those and other acetogenins are described. Bioactive cyclic formaldehyde acetal derivatives are prepared from Annonaceous acetogenins having 1,2-, 1,4- or 1,5-diols. A non-adjacent bis-tetrahydrofuran(THF) acetogenin is prepared from an unsaturated mono-THF acetogenin earlier isolated from Goniothalamus giganteus. The substantially pure acetogenins and acetogenin derivatives of the invention exhibit cytotoxicity to human solid tumor cell lines equipotent to adriamycin or orders of magnitude more potent than adriamycin, and they exhibit effective pesticidal activities.

REFERENCES:
patent: 4721727 (1988-01-01), Mikolajczak et al.
patent: 4855319 (1989-08-01), Mikolajczak et al.
patent: 5229419 (1993-07-01), McLaughlin et al.
Gu, Zhe-ming et al., "New Cytotoxic Annonaceous Acetogenins: Bullatanocin and cis-trans-Bullatanocinone From Annona bullata (Annonaceae)", 1993, Tetrahedron, vol. 49, p. 747.
Gu, Zhe-ming et al., "Bullacin: A New Cytotoxic Annonaceous Acetongenin From Annona bullata", 1993, Heterocycles, vol. 36, No. 10, pp. 2221-2228.
Gu, Zhe-ming et al., "30-, 31-, and 32-Hydroxybullatacinones: Bioactive Terminally Hydroxylated Annonaceous Acetongenins from Annona bullata", Jun. 1993, Journal of Natural Products, vol. 56, No. 6, pp. 870-876.
Rupprecht, J. Kent et al., "Annonaceous Acetogenins: A Review", Mar.-Apr. 1990, Journal of Natural Products, vol. 53, No. 2, pp. 237-278.
Fang, Xin-ping et al., "Annonaceous Acetogins: An Updated Review and Appendices", 1993, Phytochemical Analysis, vol. 4, pp. 27-67.
Fang, Xin-ping et al, "A New Type of Cytotoxic Annonaceous Acetogenin: Giganin from Goniothalamus giganteus", 1993, Bioorganic & Medicinal Chem. Letters, vol. 3, No. 6, pp. 1153-1156.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bioactive acetogenins and derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioactive acetogenins and derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioactive acetogenins and derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1785577

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.