Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined...
Reexamination Certificate
2000-04-17
2002-04-02
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
C424S093600, C424S665000, C423S324000, C423S326000, C514S210030
Reexamination Certificate
active
06365192
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a highly active bioactivating substance having a high silicon component content. The bioactivating substance may be obtained by adding a silicate to an extracted substance from tissues activated by adding internal or external stressors to animals or animal tissues, or by carrying out a special extraction to make the content of silicic acid high in the extracted substance from the activated tissues.
BACKGROUND OF THE INVENTION
Living organisms survive as an individual by adjusting and maintaining their physical and chemical states to and within certain stable physiological conditions by adapting to the changes in internal and external circumstances. To maintain such homeostasis, the living organism always produces various substances in vivo. Upon invasion by viruses or bacteria, and upon generation of tumor cells, it also produces resistant substances in vivo to such external and internal invasions.
However, when the biofunctional balance is disturbed and the unbalanced state becomes chronic, various diseases result. The ideal way of curing the disease is to recover from the abnormal state of the unbalanced biofunction to a normal state by invigorating and regulating homeostasis of the living body. It is well known that various receptors and ion channels such as sodium, potassium and calcium channels on cell surfaces especially carry out the maintenance and normalization of biofinctions. It is also known that, upon growing older, the ability of DNA to recover against damage decreases in mammalian cells and that the production of free radicals in vivo promotes aging and the generation of collagen disease and cancer. Collagen is a noncellular substance widely present in skin, blood vessels, cartilage, eyeballs and kidneys. A crosslinking of collageneous materials proceeds with aging and their elasticity decreases and they become hard.
Histamine is released from mast cells upon the antigen-antibody reaction and causes various allergic reactions. A suppressive ability for mast cell degranulation may contribute to normalization of the abnormal diseased state.
The present inventor has focused on the homeostatic functions of a living body, which regulate and restore the neurological, immunological and endocrinological disturbances due to functional abnormality in the diseased state. He has conducted an extensive investigation to ascertain resistant substances produced in vivo to external and internal stresses. As a result of such investigations on substances produced from activating living tissues, which enhance the natural curing activity and normalize the functions of a living body, the present inventor has found a highly active bioactivating substance and accomplished the present invention.
In the present invention, a high silicon component content, bioactivating substance is obtained from an extract from activated or stressed tissues and a silicate. The bioactivating substance of the invention is a biofunction-regulating and maintaining substance which may cure and normalize the abnormal functions occurring in a diseased state. It exhibits physiological activities such as unexpectedly superior suppressing action on histamine liberation and inhibition of hyaluronidase activity. It may be employed in pharmaceutically effective amounts in pharmaceutical compositions for the treatment of allergies in patients known to be in need of such treatment.
SUMMARY OF THE INVENTION
The present invention provides a highly active bioactivating substance comprising an extract from activated tissue. The bioactivating substance has a silicon component content of greater than 20 &mgr;g, for example greater than 22 &mgr;g, preferably greater than 25 &mgr;g, which is calculated as silicon per mg of dried substance. To obtain the bioactivating substance of the present invention, various animals or animal tissues are inoculated with viruses or tumor cells as a stressor to activate the tissues, a physiologically active substance is extracted from the activated tissue and a soluble silicate is added thereto, The bioactivating substance of the present invention may also be prepared by a special extracting method to obtain a high content of silicic acid in the extracted substance from the activated tissue. In embodiments of the present invention, the ratio of the silicon component content of the extract from the activated tissue calculated as silicon to the total silicon component content of the bioactivating substance calculated as silicon is 1:3 to 1:10. The bioactivating substance of this invention exhibits physiological activities such as unexpectedly high suppressing action on histamine liberation and inhibition of hyaluronidase activity. The bioactivating substance of the invention is a biofunction-regulating and maintaining substance which may cure and normalize abnormal functions occurring in a diseased state.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides a bioactivating substance which suppresses histamine liberation from mast cells and inhibits hyaluronidase activity comprising an extract from activated tissue. The extract and the bioactivating substance containing it comprise at least one silicon component. In embodiments of the invention, at least one additional silicon component is admixed with the extract from activated tissue to obtain a mixture, and the mixture is dried to obtain a powder form of the bioactivating substance of the present invention. The bioactivating substance of the present invention, and the dried extract from the activated tissues, exhibit positive color reactions to amino acid (by a ninhydrin reaction), saccharide (by an orcinol-iron (III) chloride-hydrochloric acid method), phosphorus (by a molybdenum blue method) and silicic acid (by a molybdenum blue method), and negative qualitative reactions to protein (by a trichloroacetic acid method) and phenol (by a ferric chloride method). The bioactivating substance of the present invention obtained by admixing the extract from the activated tissue and the additional silicon component, has a silicon component content which is more than 20 &mgr;g calculated as silicon per mg of dried substance. The additional silicon component substantially increases the silicon component content of the extract from activated tissues and substantially increases its physiological activity. In embodiments of the present invention, the bioactivating substance may have a silicon component content of greater than 22 &mgr;g, preferably greater than 25 &mgr;g, which is calculated as silicon per mg of dried substance. The ratio of the silicon component content of the extract from the activated tissue calculated as silicon to the total silicon component content of the bioactivating substance calculated as silicon may be 1:3 to 1:10. The total silicon component content of the bioactivating substance includes silicon components naturally or originally present in the extract from activated animal tissues and any silicon components contributed by admixing the extract with additional silicon components not naturally or originally present in the extract from activated animal tissues.
The bioactivating substance may be obtained by activating or stressing animal tissue, grinding the activated animal tissues, adding a solvent for extraction to the ground tissue, removing the tissue pieces, removing protein from the remaining mixture, adsorbing the residue with an adsorbent, eluting the adsorbed components from the adsorbent, and then adding a predetermined amount of a soluble silicate to the resulting physiologically active substance as extracted above. The bioactivating substance of the present invention can also be obtained by a special extracting method,.i.e., all eluting operation from the adsorbent is carried out to make the content of silicic acid high.
In embodiments of the invention, extracts from an activated tissue which may be employed in the compositions and methods of the present invention may be extracts from inflammatory tissue inoculated with vaccinia virus disclosed i
Hollander Law Firm, P.L.C.
Nippon Zoki Pharmaceutical Co. Ltd.
Tate Christopher R.
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