Bioabsorbable triglycolic acid poly(ester-amide)s

Details Bioabsorbable triglycolic acid poly(ester-amide)s Bioabsorbable triglycolic acid poly(ester-amide)s

1998-10-16

2000-09-19

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

528291, A61L 1700, C08G 6944

Patent

active

061207888

ABSTRACT:
This invention relates to fiber-forming bioabsorbable poly(ester-amide)s made by the polymerization of diamidediols with 3,6-dioxaoctanedioic acid, also known as "triglycolic acid". More specifically it relates to diol terminated poly(ester-amide)s of triglycolic acid that are optionally further reacted with glycolide, lactide, trimethylene carbonate, epsilon-caprolactone, or p-dioxanone, or mixtures of said cyclic monomers to produce the corresponding block copolymers. Said polymers are useful in the production of surgical sutures having superior performance characteristics including low bending stiffness and in the production of other fiber-based bioabsorbable implants and molded devices.

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Katayama, et al. "Synthesis of Alternating Polyamide Esters by Melt and Solution Polycondensations of N,N'-Di(6-hydroxycaproyl) dimines and N-6-Hydroxycaproyl Aminoalcohol with Terephthalic and Adipic Dimethyl Esters and Dichlorides" J. of Applied Polymer Science; 20: 975-994.

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