Bioabsorbable polymer containing 2-hydroxyacid monomers

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S320100, C435S004000, C435S190000, C435S193000, C435S189000, C536S023200

Reexamination Certificate

active

08039237

ABSTRACT:
Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing 2-hydroxyacid monomers can be synthesized via biosynthesis by the action of a PHA polymerase in a living cell. By changing the genetic background of the cells, one can control specific metabolic pathways allowing control of the level of glycolic acid co-monomer in the PHA polymer.

REFERENCES:
patent: 3736646 (1973-06-01), Schmitt et al.
patent: 3867190 (1975-02-01), Schmitt et al.
patent: 4910145 (1990-03-01), Holmes et al.
patent: 5245023 (1993-09-01), Peoples et al.
patent: 5250430 (1993-10-01), Peoples et al.
patent: 5480794 (1996-01-01), Peoples et al.
patent: 5489470 (1996-02-01), Noda
patent: 5512669 (1996-04-01), Peoples et al.
patent: 5520116 (1996-05-01), Toyre
patent: 5534432 (1996-07-01), Peoples et al.
patent: 5563239 (1996-10-01), Hubbs et al.
patent: 5973100 (1999-10-01), Asrar et al.
patent: 6329183 (2001-12-01), Skraly et al.
patent: 6548569 (2003-04-01), Williams et al.
patent: 6576450 (2003-06-01), Skraly et al.
patent: 6610764 (2003-08-01), Martin et al.
patent: 2002/0164729 (2002-11-01), Skraly et al.
patent: 2003/0017576 (2003-01-01), Aquin et al.
patent: 2004/0023347 (2004-02-01), Skraly et al.
patent: 2005/0239179 (2005-10-01), Skraly et al.
patent: WO 99/32536 (1999-07-01), None
patent: WO 00/08198 (2000-02-01), None
patent: WO 00/56376 (2000-09-01), None
patent: WO 02/08428 (2002-01-01), None
patent: WO 02/40690 (2002-05-01), None
Anderson et al. Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev. Dec. 1990;54(4):450-72.
Johnson et al.Klebsiella pneumoniae1,3-propanediol:NAD+ oxidoreductase. J Bacteriol. May 1987;169(5):2050-4.
Hein et al. Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains ofEscherichia coli. FEMS Microbiol Lett. Aug. 15, 1997;153(2):411-8.
Sophos et al. Aldehyde dehydrogenase gene superfamily: the 2000 update. Chem Biol Interact. Jan. 30, 2001;130-132(1-3):323-37.
Tsuge et al. Molecular cloning of two (R)-specific enoyl-CoA hydratase genes fromPseudomonas aeruginosaand their use for polyhydroxyalkanoate synthesis. FEMS Microbiol Lett. Mar. 15, 2000;184(2):193-8.
Expasy Enzyme Nomenclaure Database: aldehyde dehydrogenase.
Expasy Enzyme Nomenclaure Database: diol oxidoreductase.
Madison et al. Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic. Microbiol Mol Biol Rev. Mar. 1999;63(1):21-53.
Skraly. Polyhydroxyalkanoates Produced by RecombinantE. coli, Poster at Engineering Foundation Conference: Metabolic Engineering, 1998.
Steinbuchel et al. (FEMS Microbiology Letters 128 )1995) 219-228.
BRENDA database—“EC 1.1.1.202”.
Nunez et al. Biochemical characterization of the 2-ketoacid reductases encoded by ycdW and yiaE genes inEscherichia coli. Biochem J. Mar. 15, 2001;354(Pt 3):707-15.
Valentin, et al., “Application of a Propionyl Coenzyme a Synthetase for Poly (3-hydroxypropionate-co-3-Hydroxybutyrate) Accumulation in RecombinantEscherichia coli,” Appl. Environ. Microbiol.66(12): 5253-5258 (2000).
Sudesh, et al., “Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters”,Prog. Polym. Sci., 25(10):1503-55 (2000).
Zinn, et al., “Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate”,Adv. Drug. Deliv. Rev., 53(1):5-21 (2001).
Williams, et al., “PHA applications: addressing the price performance issue: I. Tissue engineering”,Int. J. Biol. Macromol., 25(1-3):111-21 (1999).
Khelifa, et al., “Synthesis of 2-hydroxyacid from 2-amino acid byClostridium butyricum”, Bioorganic&Medicinal Chem. Lett., 8(23):3429-3434 (1998).
Skraly, et al. “Construction and characterization of a 1,3-propanediol operon”,Appl. Environ Microbiol., 64(1):98-105 (1998).
Agostini, et al., “Synthesis and Characterization of Poly-β-Hydroxybutyrate. I. Synthesis of Crystalline DL Poly-β-Hydroxybutyrate from DL-β-Butyrolactone,”Polym. Sci.Part A-1 9:2775-87 (1971).
Braunegg, et al., “Polyhydroxyalkanoates, biopolyesters from renewable resources: physiological and engineering aspects,”J. Biotech.65: 127-161 (1998).
Bruhn & Müller, “Preparation and characterization of spray-dried poly(DL-lactide) Micro Spheres,”Proceed. Intern. Symp. Control. Rel. Bioact. Mater.18:668-69 (1991).
Byrom, “Miscellaneous Biomaterials” in Biomaterials (D. Byrom, ed.) pp. 333-359 (MacMillan Publishers, London 1991).
Cao, et al., “Thermal and morphological study of fractionated poly(3-hydroxybutyric acid-co-3-hydroxypropionic acid),”Macromol. Chem. Phys.198: 3539-3557 (1997).
Choi & Lee, “Factors affecting the economics of polyhydroxyalkanoate production by bacterial fermentation,”Appl. Microbiol. Biotechnol.51: 13-21 (1999).
Chujo, et al., “Ring-opening polymerization of glycolide,”Die Makromol. Chem.100: 262-266 (1967).
Conti, et al., “Use of polylactic acid for the preparation of microparticulate drug delivery systems,”J. Microencapsulation9: 153-166 (1992).
Doi, “Microbial synthesis, physical properties, and bioegradability of polyhydroxyalkanoates,”Macromol. Symp.98: 585-599 (1995).
Dubois, et al., “Macromolecular engineering of polylactones and polylactides. 12. Study of the depolymerization reactions of pol(ε-caprolactone) with functional aluminum alkoxide end groups,”Macromolecules26:4407-4412 (1993).
Fukuzaki, et al., “A new biodegradable copolymer of glycolic acid and lactones with relatively low-molecular weight prepared by direct copolycondensation in the absence of catalysts,”J. Biomed. Mater. Res.25(3):315-328 (1991).
Fukuzaki, et al., “Direct copolymerization of glycolic acid with lactones in the absence of catalysts,”Eur. Polym. J.26(4): 457-61 (1990).
Gerngross & Martin, “Enzyme-catalyzed synthesis of poly[(R)−(−)−3-hydroxybutyrate]: formation of macroscopic granules in vitro,”Proc. Natl. Acad. Sci. USA92:6279-83 (1995).
Gross, et al., “Polymerization of β-monosubstituted-β-propiolactones using trialkylaluminum-water catalytic systems and polymer characterization,”Macromolecules21:2654-68 (1988).
Hein, et al., “Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains ofEscherichia coli,” FEMS Microbiol. Lett.153:411-418 (1997).
Herrero, et al., “Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria,”J. Bacteriol.172(11):6557-6567 (1990).
Hocking & Marchessault, “Syndiotactic poly[(R,S)-β-hydroxybutyrate] isolated from methyaluminoxane-catalyzed polymerization,”Polym. Bull.30:163-70 (1993).
Hocking & Marchessault, “Biopolyesters” inChemistry and Technology of Biodegradable Polymers, (G.J.L. Griffin, ed.), pp. 48-96, Chapman and Hall: London, 1994.
Holmes, “Biologically Produced (R)-3-Hydroxyalkanoate Polymers and Copolymers,” inDevelopments in Crystalline Polymers(Bassett, ed.) Elsevier: London, pp. 1-65 (1988).
Hori, et al., “Ring-opening copolymerization of optically active β-butyrolactone with several lactones catalyzed by distannoxane complexes: synthesis of new biodegradable polyesters,”Macromolecules26:4388-90 (1993).
Hori, et al., “Ring-opening polymerization of optically active β-butyrolactone using distannoxane catalysts: synthesis of high molecular weight poly(3-hydroxybutyrate),”Macromolecules26:5533-34 (1993).
Jesudason & Marchessualt, “Synthetic poly[(R,S)-β-hydroxyalkanoates] with butyl and hexyl side chains,”Macromolecules27: 2595-2602 (1994).
Johnson & Lin, “Klebsiella pneumoniae1,3-prop

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bioabsorbable polymer containing 2-hydroxyacid monomers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioabsorbable polymer containing 2-hydroxyacid monomers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioabsorbable polymer containing 2-hydroxyacid monomers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4301207

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.