Bioabsorbable chlorophosphate glasses and bioabsorbable glass-po

Compositions: ceramic – Ceramic compositions – Glass compositions – compositions containing glass other than...

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501 45, 501 47, 501 48, C03C 316, C03C 323

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active

052525236

ABSTRACT:
This invention is directed towards the production of a bioabsorbable glass-polymer alloy comprising a bioabsorbable glass and a bioabsorbable polymer, said glass having a working temperature below about 350.degree. C., a transition temperature no higher than about 250.degree. C., and which exhibits a dissolution weight loss rate which is similar to the rate at which a bioabsorbable polymer is absorbed by the body. Such exemplary bioabsorbable polymers include poly(lactic) acid, poly(glycolic) acid, poly(dioxanone), polyethylene terephthalate, polyethylene oxide poly(caprolactone), copolymers of lactic acid and glycolic acid, and mixtures thereof.
The glass disclosed herein consists essentially, expressed in terms of weight percent on the oxide basis, of at least 85% total of 30-55% P.sub.2 O.sub.5, 12-35% ZnO, 10-30% Cl, and 15-40% R.sub.2 O, wherein R.sub.2 O consists of at least one alkali metal oxide in the indicated proportions selected from the group consisting 5-25% Na.sub.2 O, 0-25% K.sub.2 O, and 0-7% Li.sub.2 O, and up to 15% total optional ingredients in the indicated proportions selected from the group consisting of 0-10% CaO, 0-10% MgO, 0-10% MnO, 0-10% B.sub.2 O.sub.3, 0-5% Al.sub.2 O.sub.3, 0-10% Fe.sub.2 O.sub.3 and 0-5% F.

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