Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1986-04-02
1991-05-21
Cohan, Alan
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
204403, C12M 140
Patent
active
050174940
ABSTRACT:
A bio-thermo sensor has an enzyme-modified membrane directly supported on an IC thermal detector in face-to-face contact. The enzyme-modified membrane selectively reacts with a specific chemical substance to generate therein a reaction heat which is converted into an amplified output voltage indicative of the chemical substance by the IC thermal detector. The IC thermal detector includes Darlington-connected transistors which provide high sensitivity and quick response time.
REFERENCES:
patent: 4148305 (1979-04-01), Reichenberger
patent: 4514276 (1985-04-01), Covington
patent: 4568444 (1986-02-01), Nakamura
Mosbach, et al; "Thermal Bioanalyzers in Flow Streams"; Analytical Chemistry, vol. 53, No. 1, pp. 83A-94A; Jan. 1981.
Karube Isao
Muramatsu Hiroshi
Adams Bruce L.
Cohan Alan
Seiko Instruments & Electronics Ltd.
Wilks Van C.
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