Bio-oxidation of high alcohols in non-aqueous reaction media

Details Bio-oxidation of high alcohols in non-aqueous reaction media Bio-oxidation of high alcohols in non-aqueous reaction media

1990-04-24

1991-04-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435178, 435180, 435182, 435190, 435938, C12R 184, C12P 724

Patent

active

050100050

ABSTRACT:
Whole cells of methylotrophic yeasts are able to oxidize benzyl alcohol to benzaldehyde in aqueous reaction media. However, the low water solubility of the reactant and product of this bioconversion, combined with the ability of both to strongly inhibit the reaction, suggested to us the use of non-aqueous reaction fluids. Using non-aqueous systems, it was found that Pichia pastoris can be used to oxidize higher alcohols. The alcohol oxidase from such yeast had been previously reported unable to oxidize such alcohols. Purified alcohol oxidase was shown to function in a number of two-phase systems of varied aqueous to organic phase concentrations. The stability and biocatalyst recovery of the enzyme was improved by immobilization.

REFERENCES:
patent: 4871669 (1989-10-01), Murray et al.

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