Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Ion exchange resin
Patent
1990-12-19
1992-11-10
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Ion exchange resin
424 781, A61K 3174, A61K 914
Patent
active
051621100
ABSTRACT:
In a method in which an ionizable pharmaceutical material, such as theophylline, having a pharmaceutically-active anionic group is bonded to an anion exchange resin having cationic groups bonded to displacable anionic groups by bringing said material and said resin into contact with each other under conditions such that the pharmaceutically-active anionic group of said material is bonded to the cationic group of said resin and replaces the anionic group thereof, the improvement comprising effecting said contact in an environment which is substantially free of carbon dioxide and/or bicarbonate ion, a pharmacologically active composition comprising said pharmaceutically active anion and said resin, including a composition in which at least about 40% of the binding capacity of the resin comprises said pharmaceutically active anion, and a sustained release pharmaceutical composition, including enteric coated particles of the composition, and stabilizing said composition by maintaining it in an environment substantially free of bicarbonate and/or carbon dioxide.
REFERENCES:
patent: 3109775 (1963-11-01), Shepard et al.
patent: 3143465 (1964-08-01), Keating
patent: 3594470 (1971-07-01), Borodkin et al.
patent: 4261970 (1981-04-01), Ogawa et al.
patent: 4996047 (1991-02-01), Kelleher et al.
Chrzan Zofia J.
Warchol Mark P.
Barron Alexis
Kulkosky Peter F.
Nicholson James A.
Page Thurman K.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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