Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1991-05-31
1994-01-11
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
424 9, 436 64, 436503, 436543, 436813, 5303877, 53038825, 5303893, 530828, A61K 4900, C07K 1506, C07K 1514, G01N 3350
Patent
active
052782905
ABSTRACT:
Disclosed is a protein that specifically binds carcinoembryonic actigen (CEA) in the presence of divalent cation in vitro. This protein has a molecular weight of about 21 kD as determined by SDS-polyacrylamide gel electrophoresis, is glycosylated, and includes the amino acid sequence set forth in the Sequence Listing as SEQ ID NO: 2. Also disclosed are antibodies that recognize the CEA binding protein, methods of detecting carcinoma, methods of treating carcinoma, and a kit for screening a patient for carcinoma.
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Briggman Joseph V.
Maswoswe Sibusisiwe M.
Thomas Peter
Toth Carol A.
Applied Biotechnology, Inc.
New England Deaconess Hospital Corp.
Russel Jeffrey E.
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