Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-10-09
1995-03-28
Kishore, G. S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4284022, A61K 9127
Patent
active
054015111
ABSTRACT:
Methodologies have been developed and certain recognizing substances and crosslinking reagents have been identified to modify liposomes. Crosslinking reagents link residues on the liposomal surface to the residues offered by certain recognizing substances. The crosslinking reagents include glutaraldehyde (GAD) and a water soluble carbodiimide, preferably, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The recognizing substances include gelatin, collagen, and hyaluronic acid (HA). Following these methodologies, recognizing substances can be utilized as an adhesive or glue to attach the liposomes onto a target area. These "bioadhesive" liposomes offer potential advantages as a microscopic drug delivery system.
REFERENCES:
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4708861 (1987-11-01), Popescu
patent: 4761288 (1988-08-01), Mezei et al.
patent: 4839175 (1989-06-01), Guo et al.
Chapter 6 of vol. III from Liposome Technology (Gregoriadis, Editor; CRC Press, Publisher; 1984; chapter on "Immobilization of Specific Proteins on Liposome Surface: Systems for Drug Targeting".
Publication from vol. 160, No. 2, 1989 of Biochemical and Biophysical Research Communications titled "Preparation of EGF Labeled Liposomes and Their Uptake By Hepatocytes".
Publication from Methods in Enzymology, vol. 70, 1980 (Reichlin, author; Academic Press, Inc., publisher) titled "Use of Glutaraldehyde as a Coupling Agent for Proteins and Peptides".
Torchillin in Liposome Technology III, p. 75 1984.
Wessig et al in Die Pharmazic 45 (1990) p. 849.
Excerpt from Patent Abstracts of Japan, vol. 9, No. 74 (C-273) (1797) dated Apr. 3, 1985.
German publication authored by V. Weissig et al, titled "Kovalente Bindug von Peptiden an liposomale Oberflachen"; pp. 849-850 of Pharmazie, vol. 45 No. 11, dated Nov. 1990.
International Application No. PCT/EP89/00521 published on Nov. 30, 1989.
International Application No. PCT/EP87/01833 published on Feb. 11, 1988.
International Application No. PCT/FR90/00176 published on Oct. 4,1990.
Baxter International Inc.
Kishore G. S.
LandOfFree
Binding of protein and non-protein recognizing substances to lip does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Binding of protein and non-protein recognizing substances to lip, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Binding of protein and non-protein recognizing substances to lip will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2248910