Binding of pathological forms of prion proteins

Details Binding of pathological forms of prion proteins Binding of pathological forms of prion proteins

2003-02-28

2010-02-09

Prouty, Rebecca E. (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S078350, C514S059000, C536S051000, C436S086000

Reexamination Certificate

active

07659076

ABSTRACT:
Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.

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