Binding of immune complexes by modified forms of C-reactive prot

Details Binding of immune complexes by modified forms of C-reactive prot Binding of immune complexes by modified forms of C-reactive prot

1994-07-06

1997-01-14

Kim, Kay K. A.

Chemistry: analytical and immunological testing

For preexisting immune complex or auto-immune disease

Immune complex

436518, 436524, 436528, 436532, 436538, 436541, 436544, 436824, 435 79, 435 792, 422 61, 604 6, G01N 33564, G01N 33543, G01N 3353, A61M 138

Patent

active

055938973

ABSTRACT:
A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.

REFERENCES:
patent: 3882225 (1975-05-01), Patel et al.
patent: 4230685 (1980-10-01), Senyei et al.
patent: 4409330 (1983-10-01), Pollard, Jr.
patent: 4418152 (1983-11-01), Hosaka et al.
patent: 4432871 (1984-02-01), Yamawski et al.
patent: 4447545 (1984-05-01), De Fazio et al.
patent: 4450239 (1984-05-01), Chatterton
patent: 4464165 (1984-08-01), Pollard, Jr.
patent: 4470967 (1984-09-01), Gough et al.
patent: 4504585 (1985-03-01), Reynolds
patent: 4551435 (1985-11-01), Liberti et al.
patent: 4608253 (1986-08-01), Obnishi et al.
patent: 4614513 (1986-09-01), Bensinger
patent: 4617262 (1986-10-01), Maxim et al.
patent: 4627915 (1986-12-01), Kuroda et al.
patent: 4634417 (1987-01-01), Korec
patent: 4656144 (1987-04-01), Hosaka et al.
patent: 4775483 (1988-10-01), Mookerjea et al.
patent: 4801449 (1989-01-01), Balint et al.
patent: 4875314 (1989-08-01), O'Connor et al.
patent: 4889816 (1989-12-01), Davis et al.
patent: 4902630 (1990-02-01), Bennett et al.
patent: 5037649 (1991-08-01), Balint et al.
patent: 5084398 (1992-01-01), Huston et al.
patent: 5272258 (1993-12-01), Siegel et al.
patent: 5283238 (1994-02-01), Potempa et al.
Ballou et al., J. Lab. Clin. Med., 115, 332-338 (1990).
Gotschlich, Ann. N.Y. Acad. Sci., 557, 9-18 (1989) Review on CRP.
Harris et al., FASEB J., 4, A 1995 (1990) Abstract No. 1759.
Horowitz et al., J. Immunol., 138, 2598-2603 (1987).
James et al., Rheumatology News, 18, 3 (1990).
Mortensen et al., J. Immunol., 119, 1611-1616 (1977).
Swanson et al., FASEB J., 4, A 1840 (1990) Abstract No. 856.
Bray et al., J. Immunol., 140, 4271-4278 (1988).
Chu et al., Proc. Amer. Acad. Cancer Res., 28, 344 (1987) Abstract No. 1362.
Chu et al., Proc. Amer. Acad. Cancer Res., 30, (1989) Abstract p. 48.
Bristow et al., Molec. Immunol., 23, 1045-1052 (1986).
deBeer et al., J. Exp. Med., 154, 1134-1149 (1981).
Fiedel et al., J. Immunol., 131, 1416-1419 (1983).
Floyd-Smith et al., Imnmunogenetics, 24, 171-176 (1986).
Gewurz et al., FASEB J., 4, A 2198 (1990) Abstract No. 2911.
Ku et al., FASEB J., 4, A 1770 (1990) Abstract No. 449.
Mantzouranis et al., J. Biol. Chem., 260, 7752-56 (1985).
Pepys et al., Clin. Exp. Immunol., 38, 284-93 (1979).
Prelli et al., J. Biol. Chem., 260, 12895-98 (1985).
Burton et al., Nature, 288, 338-344 (1980).
Duncan et al., Nature, 332, 738-740 (1988).
Hughes-Jones et al., Immunol., 34, 459-463 (1978).
Lancet et al., Biochem. Biophys. Res. Commun., 85, 608-614 (1978).
Langone, Adv. Immunol., 32, 157-252 (1982).
Langone et al., J. Immunol., 121, 327-332 (1978).
Lukas et al., J. Immunol., 127, 2555-2560 (1981).
Veerhuis et al., Eur. J. Immunol., 15, 881-887 (1985).
Jones et al., Plasma Ther. Transfus. Technol., 7, 333-349 (1986).
Jones et al., J. Immunological Methods, 53, 201-208 (1982).
Levinson et al., J. Clin. Immunoassay, 7, 328 (1984).
Harris et al, FASEB J., 4, A 1893 (1990) Abstract No. 1163.
Iturralde et al., Revista Espa nola de Fisiologia, 40, 279-288 (1984).
Kinoshita et al., Biochem., 28, 9840-48 (1989).
Rees et al., Clin. Res., 37, 559A (1989) Abstract.
Ying et al., FASEB J., 3, A 1345 (1989) Abstract No. 6504.
Ying et al., J. Immunol., 143, 221-228 (1989).
Baltz et al. (1982) Biochim Biophys Acta 701:229-236.
Anderson et al., Immunol. Today, 7, 264-66 (1986).
Baltz et al., Ann N.Y. Acad. Sci., 389, 49-75 (1982).
Barna et al., Cancer Res., 44, 305-310 (1984).
Barna et al., Cancer Res., 47, 3959-63 (1987).
Bertram et al., J. Biol. Resp. Mod., 3, 235-240 (1984).
Blair et al., J. Immunol. Methods, 59, 129-143 (1983).
Boackle et al., Nature, 282, 742-43 (1979).
Bombardieri et al., J. Art. Org., 6, 47-50 (1983).
Bray et al., Clin Immunol. Newsletter, 8, 137-140 (1987).
Bray et al., Clin. Res., 35, 889A (1987).
Bruneau et al., J. Clin. Invest., 64, 191-198 (1979).
Burton, Molec. Immunol., 22, 161-206 (1985).
Chu et al., Proc. Amer. Assoc. Cancer Res., 29, 371 (1988) Abstract No. 1477.
Chudwin et al., J. Allergy Clin. Immunol., 77, 216a (1986).
Colbert et al., J. Biol. Resp. Mod., 3, 255-59 (1984).
Creighton et al., J. Immunol., 111, 1219-1227 (1973).
Deodhar et al., Cancer Res., 42, 5084-88 (1982).
Dobre et al., J. Immunol. Meth., 66, 171-178 (1984).
Dougherty et al., Protides of the Biological Fluids, 34, 291-293 (1986).
Emancipator et al., Lab. Invest., 54, 475-478 (1986).
Feldmann et al., J. Exp. Med., 131, 247-274 (1970).
Feldkamp, Clin. Chem. News, 4, 5-6 (1987).
Friquet et al., Molec. Immunol., 21, 673-77 (1984).
Gauthier et al., J. Exp. Med., 156, 766-777 (1982).
Gewurz et al., Advances in Internal Medicine, 27, 345-72 (1982).
Gotschlich et al., Proc. Nat'l Acad. Sci., 57, 706-712 (1967).
Gupta et al., Arthritis and Rheumatism, 31, R39a, (1988) Abstract No. 325.
Gupta et al., Journal of Immunology, 137, 2173-2179 (1986).
Hay et al., Clin. Exp. Immunol., 24, 396-400 (1976).
Ingram, Animal Models of Immunological Processes, 221-253 (1982) J. Hay ed, Academic Press, London.
James, Dissertation Abstracts International, 41/08-B, 2963 (1980).
Jones et al., Cancer, 46, 675-84 (1980).
Kaplan et al., J. Immunol., 112, 2135-2147 (1974).
Kearney et al., Immunological Communications, 11, 275-282 (1982).
Kilpatrick and Volanakis, J. Immunol., 134, 3364-70 (1985).
Kinoshita, F.A.S.E.B. J., 2, A1149 (1988) Abstract No. 4959.
Kulkarni et al., Cancer Res., 41, 2700-2706 (1981).
Lai et al., Artifical Organs, 11, 259-264 (1987).
Lei et al., J. Biol. Chem., 260, 13377-83 (1985).
Levinsky et al., Lancet, i, 564-67 (1977).
Levinson et al., J. Clin. Immunoassay, 7, 328-336 (1984).
Liberti et al., J. Immunol., 123, 2212-2219 (1979).
Liberti, Opportunities in the Oncology Marketplace (Slide presentation). Date ?.
Maire et al., Clin. Exp. Immunol., 51, 215-224 (1983).
Malchesky et al., Cleveland Clinic Quarterly, 50, 11-18 (1983).
Mantzouranis et al., Ped. Res., 18, 260A (1984) Abstract No. 987.
Maudsley and Pepys, Immunology, 62, 17-22 (1987).
McDougal et al., Adv. Clin. Chem., 24, 1-60 (1985).
Mingari et al., J. Immunol., 121, 767-770 (1978).
Mold et al., J. Exp. Med., 154, 1703-1708 (1981).
Mortensen, et al., J. Immunol., 117, 774-781 (1976).
Nakayama et al., J. Immunol., 128, 2435-2438 (1982).
Nakayama et al., J. Immunol., 132, 1336-1340 (1984).
Nauts, Host Defense Against Cancer and Its Potentiation, 337-351 (1975).
Mizuno et al Eds, Univ Tokyo Press, Tokyo.
Nguyen et al., J. Biol. Chem., 261, 10450-10455 (1986).
Nilsson et al., Plasma. Ther. Transfers. Technol., 5, 127-134 (1984).
Nilsson et al., Scand. J. Haematol., 30, 458-464 (1983).
Nilsson et al., Factor VIII Inhibitors, 225 (1984).
Nilsson, Int. Arch. Allergy, 32, 545-62 (1967).
Osmand et al., Proc. Nat'l Acad. Sci., 74, 1214-1218 (1977).
Pereira et al., J. Immunol., 125, 763-770 (1980).
Perussia et al., J. Immunol., 133, 180-89 (1984).
Potempa et al., Mol. Immunol., 24, 531-41 (1987).
Potempa et al., J. Immunol., 127, 1509-1514 (1981).
Potempa et al., Protides of the Biological Fluids, 34, 287-290 (1986).
Potempa et al., Inflammation, 12, 391-405 (1988).
Potempa et al., Mol. Immunol., 20, 1165-1175 (1983).
Randerson et al., Artificial Organs, 6, 43-49 (1982).
Rawer et al., J. Art. Org., 6, 97-101 (1983).
Ritzmann et al., Clin. Chem., 28, 1259-71 (1982).
Rizk et al., Cancer, 58, 55-61 (1986).
Robey et al., J. Biol. Chem., 262, 7053-57 (1987).
Samberg et al., Cell. Immunol., 1

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