Binding of antibody reagents to denatured protein analytes

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

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530362, 530363, 530380, 530395, 530808, 424 88, 424 89, 435 7, 436514, 436548, 436 86, 436 87, 436819, A61K 3900, G01N 3356

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046580220

ABSTRACT:
Binding of a particular protein by an antibody reagent involving denaturation of the protein and use of an antibody reagent specific for binding a linear peptide epitope therein. Denaturation by chemical or physical means effectively exposes or enhances the exposure of the linear peptide epitope for binding by the antibody reagent which is preferably raised against a synthetic peptide immunogen. The technique is particularly useful in performing immunoassays for protein analytes, such as a glycosylated protein, in aqueous test samples.

REFERENCES:
patent: 4247533 (1981-01-01), Cerami et al.
patent: 4423034 (1983-12-01), Nakagawa et al.
patent: 4478744 (1984-10-01), Mezei et al.
Clinical Chemistry, vol. 30, No. 11, Nov. 1984, pp. 1746-1752.

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