Binding molecules to the human OX40 receptor

Details Binding molecules to the human OX40 receptor Binding molecules to the human OX40 receptor

2011-06-14

2011-06-14

Ouspenski, Ilia (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C424S130100

Reexamination Certificate

active

07960515

ABSTRACT:
The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

REFERENCES:
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patent: WO 03/106498 (2003-12-01), None
patent: WO2006039418 (2006-04-01), None
patent: WO 2007/062245 (2007-05-01), None
Xie, F. et al., “Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues”, Tissue Antigens, vol. 67, No. 4, pp. 307-317, Apr. 2006.
Kjaergaard, J et al., “Therapeutic Efficacy of OX-40 Receptor Antibody Depends on Tumor Immunogenicity and Anatomic Site of tumor Growth”, Cancer Research, vol. 60, No. 19, pp. 5514-5521, Oct. 1, 2000.
Kjaergaard, J. et al., “Augmentation Versus Inhibition: Effects of Conjunctional Ox-40 Receptor Monoclonal Antibody and IL-2 Treatment on Adoptive Immunotherapy of Advanced Tumor”, Journal of Immunology, vol. 167, No. 11, pp. 6669-6677, Dec. 1, 2001.
Weinberg, A. et al., “Anti OX40 (CD134) Administration to Nonhuman Primates: Immunostimulatory Effects and Toxicokinetic Study”, Journal of Immunotherapy, vol. 29, No. 6, pp. 575-585, Nov. 1, 2006.

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