Binding molecules for human factor VIII and factor VIII-like...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S344000, C530S501000, C530S501000, C435S235100, C435S007100, C514S014800

Reexamination Certificate

active

07112438

ABSTRACT:
It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.

REFERENCES:
patent: 4749780 (1988-06-01), Andersson et al.
patent: 4757006 (1988-07-01), Toole, Jr. et al.
patent: 4868112 (1989-09-01), Toole, Jr.
patent: 4877614 (1989-10-01), Andersson et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5661008 (1997-08-01), Almstedt et al.
patent: 5817752 (1998-10-01), Yu
patent: 5994310 (1999-11-01), Buettner et al.
patent: WO 97/46251 (1997-12-01), None
Bahou et al., “A Monoclonal Antibody to von Willebrand Factor (vWF) Inhibits Factor VIII Binding. Localization of its Antigenic Determinant to a Nonadecapeptide at the Amino Terminus of the Mature vWF Polypeptide,”J. Cin. Invest., 84:56-61 (1989).
Houghten, R., “General Method for the Rapid solid-Phase Synthesis of Large Numbers of Peptides: Specificity of Antigen-Antibody Interaction at the Level of individual Amino Acids,”Proc. Natl. Acad. Sci. USA, 82:5132-5135 (1985).
Jorieux et al., “Fine Epitope Mapping of Monoclonal Antibodies to the NH2-Terminal Part of von Willebrand Factor (vWF) by Using Recombinant and Synthetic Peptides: Interest for the Localization of the Factor VIII Binding Domain,”Br. J. Haematol., 87: 113-118 (1994).
Kelley et al., “Folding of Eukaryotic Proteins Produced inEscherichia coli,” Genetic Engineering, 12:1-19 (1990).
Lind et al., “Novel Forms of B-Domain-Deleted Recombinant Factor VIII Molecules. Construction and Biochemical Characterization,”Eur. J. Biochem., 232:19-27 (1995).
Merrifield, R., “Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide,”J. Am. Chem. Soc., 85:2149-2154 (1963).
Ware et al., “Localization of a Factor VIII-Inhibiting Antibody Epitope to a Region between Residues 338 and 362 of Factor VIII Heavy Chain,”Proc. Natl. Acad. Sci. USA, 85:3165-3169 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Binding molecules for human factor VIII and factor VIII-like... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Binding molecules for human factor VIII and factor VIII-like..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Binding molecules for human factor VIII and factor VIII-like... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3585181

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.