Binding member which binds to both Lewis y and Lewis b...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C435S325000, C530S387100

Reexamination Certificate

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10476233

ABSTRACT:
The invention relates to the use of a binding member which binds to Lewisyand Lewisbhaptens in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to Lewisyand Lewisbhaptens and cancer cells and induces cells death.

REFERENCES:
patent: 3773919 (1973-11-01), Boswell et al.
patent: 4485045 (1984-11-01), Regen
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5225539 (1993-07-01), Winter
patent: 5869045 (1999-02-01), Hellstrom et al.
patent: 0 036 676 (1981-09-01), None
patent: 0 052 522 (1982-05-01), None
patent: 0 058 481 (1982-08-01), None
patent: 0 088 046 (1983-09-01), None
patent: 0 120 694 (1984-10-01), None
patent: 0 125 023 (1984-11-01), None
patent: 0 143 949 (1985-06-01), None
patent: 0 184 187 (1986-06-01), None
patent: 0 142 541 (1987-07-01), None
patent: 0 239 400 (1994-08-01), None
patent: 0 285 059 (1994-11-01), None
patent: 2 188 638 (1987-10-01), None
patent: WO93/11161 (1993-06-01), None
patent: WO-94/13804 (1994-06-01), None
Durrant, 1993, Hybridoma 12:647-660.
Madjd, 2005, Breast Cancer Research, 7:R780-R787.
Rudikoff et al, 1982, PNAS, 79:1979, 83.
Burgess et al, 1990, J Cell Biol, 111:2129-2138.
Lazar et al., Mol Cell Biol, 8:1247-1252.
Wen et al, 2001, PNAS, 98:4622-4627.
Bowie, et al, Science, 1990, 257:1306-1310.
White, 2001, Ann. Rev. Med. 52:125-145.
Stedman's medical dictionary, 25th ed, 1990, p. 1652-1653.
Durrant et al, 1993 (Hybridoma, 12 (6): 647-660).
Co et al, 1996 (Cancer Res, 56: 1118-1125).
Kong et al, 1993 (Archives Biochem Biophysics, 300 (2): 677-83).
Sabbatini et al, 2000 (Intl J cancer, 87 (1): 79-85).
Pai-Scherf et al, 2000 (Clin Cancer Res, 6(5): 1720-30).
Nagai et al, 1995 ( Eur J Dermatology, 5(2): 153-155).
Luo et al, 2000, JBC, 275 (21): 16146-16154.
Lazar et al., Mol Cell Biol, 8:1247-1252, 1988.
Eppstein, D.A. et al., Biological activity of liposome-encapsulated murine interferon γ is mediated by a cell membrane receptor, Proc. Natl. Acad. Sci. USA, 82:3688-3692 (1985).
Abe, K. et al., Differential Expression of Difucosyl Type 2 Chaine (LeY) Defined by Monoclonal Antibody AH6 in Different Locations of Colonic Epithelia, Various Histological Types of Colonic Polyps, and Adenocarcinomas1, Cancer Research, 46:2639-2644 (1986).
Altschul, S.F. et al., Basic Local Alignment Search Tool, J. Mol. Biol. 215:403-410 (1990).
Altschul, S.F. et al., Gapped BLAST and PSI-Blast: a new generation of protein database search programs, Nucleic Acids Research, 25(17):3389-3402 (1997).
Bird, R.E. et al., Single-Chain Antigen-Binding Proteins, Science, 242:423-426 (1988).
Brown, A. et al., Immunohistochemical Localization of Y Hapten and the Structurally Related H Type-2 Blood-Group Antigen on Large—Bowel Tumours and Normal Adult Tissues, Int. J. Cancer, 33:727-736 (1984).
Brown, A. et al., A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains, Bioscience Reports, 3:163-170 (1983).
Durrant, L.G. et al., Flow Cytometric Screening of Monoclonal Antibodes for Drug or Toxin Targeting to Human Cancer, Journal of the National Cancer Institute, 81(9):688-696 (1989).
Holliger, P. et al., “Diabodies”: Small bivalent and bispecific antibody fragments, Proc. Natl. Acad. Sci. USA, 90:6444-6448 (1993).
Huston, J.S. et al., Protein engineering of antibody binding sites: Recovery of specific activity in an anti-digoxin single-chain Fv analogue produced inEscherichia coli, Proc. Natl. Acad. Sci. USA, 85:5879-5883 (1988).
Hwang, K.J. et al., Hepatic uptake and degradation of unilamellar sphingomyelin/cholesterol liposomes: A kinetic study, Proc. Natl. Acad. Sci. USA, 77(7):4030-4034 (1980).
Iwata, J. et al., High Frequency of Apoptosis in Infantile Capillary Haemangioma, Journal of Pathology, 179:403-408 (1996).
Karlin, S. et al., Applications and statistics for multiple high-scoring segments in molecular sequences, Proc. Natl. Acad. Sci. USA, 90:5873-5877 (1993).
Karlin, S. et al., Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes, Proc. Natl. Acad. Sci. USA, 87:2264-2268 (1990).
Kim, Y.S. et al., Expression of LeYand Extended LeYBlood Group-related Antigens in Human Malignant, Premalignant, and Nonmalignant Colonic Tissues, Cancer Research, 46:5985-5992 (1986).
Langer, R., Controlled release of macromolecules, Chemtech, 12:98-105 (1982).
Langer, R. et al., Biocompatibility of polymeric delivery systems for macromolecules, Journal of Biomedical Maerials Research, 15:267-277 (1981).
Pearson, W.R. et al., Improved tools for biological sequence comparison, Proc. Natl., Acad. Sci. USA, 85:2444-2448 (1988).
Pluckthun, A., Antibody Engineering: Advances from the Use ofEscherichia coliExpression Systems, Bio/Technology, 9:545-551 (1991).
Reff, M.E., High-level production of recombinant immunoglobulins in mammalian cells, Current Opinion in Biology, 4:573-576 (1993).
Sidman, K.R. et al., Controlled Release of Macromolecules and Pharmaceuticals from Synthetic Polypeptides Based on Glutamic Acid, Biopolymers, 22:547-556 (1983).
Terada, T. et al., Detection of Apoptosis and Expression of Apoptosis-Related Proteins during Human Intrahepatic Bile Duct Development, American Journal of Pathology, 146(1):67-74 (1995).
Terada, T. et al., Expression of apoptosis, proliferating cell nuclear antigen, and apoptosis-related antigens(bcl-2, C-myc, Fas, Lewis(Y) and p53) in human cholangiocarcinomas and hepatocellular carcinomas, Pathol. Int., 46:764-770 (1996).
Torelli, A. et al., ADVANCE and ADAM: two algorithm for the analysis of global similarity between homologous informational sequences, Comput. Appl. Biosci., 10(1):3-5 (1994).
Trill, J.J. et al., Production of monoclonal antibodies in COS and CHO cells, Current Opinion in Biotechnology, 6:553-560 (1995).
Ward, E.S. et al., Binding activities of a repertoire of single immunoglobulin variable domains secreted fromEscherichia coli, Nature, 341:544-546 (1989).
Yamada, T. et al., Induction of LeyAntigen by 5-Aza-2′-deoxycytidine in Association with Differentiation and Apoptosis in Human Pancreatic Cancer Cells, Anticancer Research, 16:735-740 (1996).
Durrant, L.G. et al., Development of Second Generation Monoclonal Antibodies Recognising Lewisy/bAntigen by Anti-Idiotypic Immunisation, Hybridoma, 12(6):647-660 (1993).

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