Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2006-03-28
2006-03-28
Canella, Karen A. (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007800, C435S007920, C536S063000
Reexamination Certificate
active
07018791
ABSTRACT:
The present invention relates to binding members that are capable of binding to and effecting the function of proteins useful in facilitating folding of large polypeptides. The present invention particularly relates to the chaperone CCT. The invention provides materials and methods for effecting the biological activity of CCT within the cell so as to prevent the folding to CCT substrates such as actin, tubulin or cyclin. The inventors provide specific binding members capable of occupying a CCT substrate binding site thereby preventing the substrate from binding. Further, the present invention provides methods for screening for such binding members which effect the biological activity of CCT.
REFERENCES:
patent: 2 270 076 (1994-03-01), None
patent: WO 93/25681 (1993-12-01), None
patent: WO 95/20654 (1995-08-01), None
patent: WO 98/13496 (1998-04-01), None
patent: WO 98/24909 (1998-06-01), None
Kim et al, Trends in Biochemical Sciences, 1994, vol. 19, pp. 543-548.
Smith et al (Abstract from the 9th International Congress on Immunology, 1995, pp. 671, abstract # 3982).
Kubota et al (Gene, 1995, vol. 154, pp. 231-236).
Hynes et al (Electrophoresis, 1996, vol. 17, pp. 1720-1727).
Anthony K.F. Liou & Keith R. Sillison, “Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes”, The EMBO Journal, vol. 16 No. 14 pp. 4311-4316, 1997, Oxford University Press, XP002079764.
Judith Frydman and Jörg Höhfeld, “Chaperons get in touch: the Hip-Hop connection”, TIBS Mar. 22, 1997, pp. 87-92, Elsevier-Science Ltd.
Hynes Gillian
Liou Anthony Kian-Fong
Willison Keith
Cancer Research Campaign - Technology Limited
Canella Karen A.
Dann Dorfman Herrell and Skillman
Institute of Cancer Research: Royal Cancer Hospital
Rigaut Kathleen D.
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