Binding compentent oligomers containing unsaturated 3',5' and 2'

Details Binding compentent oligomers containing unsaturated 3',5' and 2' Binding compentent oligomers containing unsaturated 3',5' and 2'

1993-10-26

1995-07-18

Ziska, Suzanne E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2433, 536 245, 536 253, 536 251, 536 252, C07H 1900, C07H 2100

Patent

active

054342570

ABSTRACT:
Oligonucleotide analogs having one or more substitute linkages of the formula 2'/3'--S--CH.sub.2 --CH.dbd.5' or 2'/3'--O--CH.sub.2 --CH.dbd.5' between adjacent nucleomonomers are disclosed. The substitute linkage replace the usual phosphodiester linkage found in unmodified nucleic acids. The oligonucleotide analogs are easy to synthesize, stable in vivo, resistant to endogenous nucleases and are able to hybridize to target nucleic acid sequences in a sequence specific manner.

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